Human BP-1 Recombinant Protein (RPPB2904)

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SKU:
RPPB2904
Product type:
Recombinant Protein
Size:
5ug
Species:
Human
Target:
BP-1
Synonyms:
Homeobox protein DLX-4
Synonyms:
DLX-7
Synonyms:
DLX-8
Synonyms:
Beta protein 1
Source:
Escherichia Coli
Uniprot:
Q92988
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Description

Product Name:Human BP-1 Recombinant Protein
Product Code:RPPB2904
Size:5µg
Species:Human
Target:BP-1
Synonyms:Homeobox protein DLX-4, DLX-7, DLX-8, Beta protein 1, BP1, DLX7, DLX8, DLX9, DLX4.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:BP-1 protein in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.
Stability:Store vial at -20°C to -80°C. When stored at the recommended temperature, this protein is stable for 12 months.Please prevent freeze-thaw cycles.

BP-1 gene, a member of the DLX homeobox gene family, is overexpressed in 80% of breast cancer patients, and thus represents a potential new target for diagnosis and treatment.Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly (Drosophila). The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function.

BP-1 Human Recombinant (aa 103-168) expressed in E.coli, shows a 35 kDa band on SDS-PAGE.The BP-1 is purified by proprietary chromatographic techniques.

UniProt Protein Function:DLX4: May play a role in determining the production of hemoglobin S. May act as a repressor. Belongs to the distal-less homeobox family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 17q21.33

Molecular Function:protein binding; sequence-specific DNA binding

Biological Process: negative regulation of transcription from RNA polymerase II promoter

NCBI Summary:Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function. [provided by RefSeq, Jul 2008]
UniProt Code:Q92988
NCBI GenInfo Identifier:85700416
NCBI Gene ID:1748
NCBI Accession:Q92988.4
UniProt Secondary Accession:Q92988,O60480, Q13265, Q6PJK0, Q9HBE0, D3DTX2, D3DTX3
UniProt Related Accession:Q92988
Molecular Weight:12,713 Da
NCBI Full Name:Homeobox protein DLX-4
NCBI Synonym Full Names:distal-less homeobox 4
NCBI Official Symbol:DLX4  
NCBI Official Synonym Symbols:BP1; DLX7; DLX8; DLX9; OFC15  
NCBI Protein Information:homeobox protein DLX-4
UniProt Protein Name:Homeobox protein DLX-4
UniProt Synonym Protein Names:Beta protein 1; Homeobox protein DLX-7; Homeobox protein DLX-8
Protein Family:Homeobox protein
UniProt Gene Name:DLX4  
UniProt Entry Name:DLX4_HUMAN
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