Human BMP 2 Recombinant Protein (RPPB0093)

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SKU:
RPPB0093
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
BMP 2
Synonyms:
BMP-2
Synonyms:
BMP2A
Source:
HEK293 Cells
Uniprot:
P12643
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Description

Product Name:Human BMP 2 Recombinant Protein
Product Code:RPPB0093
Size:10µg
Species:Human
Target:BMP 2
Synonyms:BMP-2, BMP2A.
Source:HEK293 Cells
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:The BMP2 was lyophilized from 0.67mg/ml in 2xPBS + 6% ethanol.
Solubility:It is recommended to reconstitute the lyophilized BMP-2 in sterile 4mM HCl containing 0.1% endotoxin-free recombinant HSA.
Stability:Lyophilized BMP2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BMP-2 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 95.0% as determined by analysis by SDS-PAGE.
Amino Acid Sequence:QAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNST NHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR
Biological Activity:The specific activity as determined by the dose dependent induction of alkaline phosphatase production in the ATDC-5 cell line (Mouse chondrogenic cell line) was found to be 6.53ng/ml.

BMP2 belongs to the transforming growth factor-beta (TGFB) superfamily. Bone morphogenic protein induces bone formation. BMP2 is a candidate gene for the autosomal dominant disease of fibrodysplasia (myositis) ossificans progressiva.

BMP-2 Human Recombinant produced in HEK cells is a glycosylated disulfide-linked homodimer, having a molecular weight range of 28kDa due to glycosylation. The BMP2 is purified by proprietary chromatographic techniques. 

UniProt Protein Function:Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451).
NCBI Summary:The protein encoded by this gene belongs to the transforming growth factor-beta (TGFB) superfamily. The encoded protein acts as a disulfide-linked homodimer and induces bone and cartilage formation. [provided by RefSeq, Jul 2008]
UniProt Code:P12643
NCBI GenInfo Identifier:115068
NCBI Gene ID:650
NCBI Accession:P12643.1
UniProt Related Accession:P12643
Molecular Weight:
NCBI Full Name:Bone morphogenetic protein 2
NCBI Synonym Full Names:bone morphogenetic protein 2
NCBI Official Symbol:BMP2  
NCBI Official Synonym Symbols:BDA2; BMP2A  
NCBI Protein Information:bone morphogenetic protein 2; BMP-2A; bone morphogenetic protein 2A
UniProt Protein Name:Bone morphogenetic protein 2
UniProt Synonym Protein Names:Bone morphogenetic protein 2A; BMP-2A
Protein Family:Bone morphogenetic protein
UniProt Gene Name:BMP2  
UniProt Entry Name:BMP2_HUMAN
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