Human BMP 2 Recombinant Protein (RPPB0093)
- SKU:
- RPPB0093
- Product type:
- Recombinant Protein
- Size:
- 10ug
- Species:
- Human
- Target:
- BMP 2
- Synonyms:
- BMP-2
- BMP2A
- Source:
- HEK293 Cells
- Uniprot:
- P12643
Frequently bought together:
Description
| Product Name: | Human BMP 2 Recombinant Protein |
| Product Code: | RPPB0093 |
| Size: | 10µg |
| Species: | Human |
| Target: | BMP 2 |
| Synonyms: | BMP-2, BMP2A. |
| Source: | HEK293 Cells |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The BMP2 was lyophilized from 0.67mg/ml in 2xPBS + 6% ethanol. |
| Solubility: | It is recommended to reconstitute the lyophilized BMP-2 in sterile 4mM HCl containing 0.1% endotoxin-free recombinant HSA. |
| Stability: | Lyophilized BMP2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BMP-2 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by analysis by SDS-PAGE. |
| Amino Acid Sequence: | QAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNST NHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR |
| Biological Activity: | The specific activity as determined by the dose dependent induction of alkaline phosphatase production in the ATDC-5 cell line (Mouse chondrogenic cell line) was found to be 6.53ng/ml. |
BMP2 belongs to the transforming growth factor-beta (TGFB) superfamily. Bone morphogenic protein induces bone formation. BMP2 is a candidate gene for the autosomal dominant disease of fibrodysplasia (myositis) ossificans progressiva.
BMP-2 Human Recombinant produced in HEK cells is a glycosylated disulfide-linked homodimer, having a molecular weight range of 28kDa due to glycosylation. The BMP2 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451). |
| NCBI Summary: | The protein encoded by this gene belongs to the transforming growth factor-beta (TGFB) superfamily. The encoded protein acts as a disulfide-linked homodimer and induces bone and cartilage formation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P12643 |
| NCBI GenInfo Identifier: | 115068 |
| NCBI Gene ID: | 650 |
| NCBI Accession: | P12643.1 |
| UniProt Related Accession: | P12643 |
| Molecular Weight: | |
| NCBI Full Name: | Bone morphogenetic protein 2 |
| NCBI Synonym Full Names: | bone morphogenetic protein 2 |
| NCBI Official Symbol: | BMP2 |
| NCBI Official Synonym Symbols: | BDA2; BMP2A |
| NCBI Protein Information: | bone morphogenetic protein 2; BMP-2A; bone morphogenetic protein 2A |
| UniProt Protein Name: | Bone morphogenetic protein 2 |
| UniProt Synonym Protein Names: | Bone morphogenetic protein 2A; BMP-2A |
| Protein Family: | Bone morphogenetic protein |
| UniProt Gene Name: | BMP2 |
| UniProt Entry Name: | BMP2_HUMAN |
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