Human Biglycan/BGN Recombinant Protein (RPES3420)

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SKU:
RPES3420
Product type:
Recombinant Protein
Host species:
Human Cells
Reactivity:
Human
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Human Biglycan/BGN Recombinant Protein

Biglycan is a 200-350 kD proteoglycan consisting of a 45 kD core protein and two chrondroitin/dermatan sulfate glycosaminoglycan chains. Biglycan binds to TGF-?. It also binds to collagen type I in low ionic strength (less than 3 mM phosphate) buffer. At higher ionic strengths, Biglycan does not bind to collagen type I. It enhances the inhibition effect of TGF-? on osteoclast proliferation at a concentration of 4-20 mg/ml. It also prevents the attachment of CHO cells to fibronectin, with a 50% inhibition at 17-21 mg/ml.

Product Name:Human Biglycan/BGN Recombinant Protein (RPES3420)
Product Code:RPES3420
Size:10µg
Species:Human
Expressed Host:Human Cells
Synonyms:Biglycan, Bone/Cartilage Proteoglycan I, PG-S1, BGN, SLRR1A
Accession:P21810
Sequence:Glu20-Lys368
Fusion tag:C-6His
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human Biglycan is produced by our Mammalian expression system and the target gene encoding Glu20-Lys368 is expressed with a 6His tag at the C-terminus.
Purity:> 95 % as determined by reducing SDS-PAGE.
Mol Mass:40.5 kDa
AP Mol Mass:50 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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