Human BCL2L2 Recombinant Protein (RPPB2875)

(No reviews yet) Write a Review

제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.

주문
SKU:
RPPB2875
Product type:
Recombinant Protein
Size:
25ug
Species:
Human
Target:
BCL2L2
Synonyms:
B-Cell Lymphoma Protein 2
Synonyms:
BCL2 Like 2
Synonyms:
BCL2 Like protein 2
Synonyms:
BCLW
Source:
Escherichia Coli
Uniprot:
Q92843
€0.00
Frequently bought together:

Description

Product Name:Human BCL2L2 Recombinant Protein
Product Code:RPPB2875
Size:25µg
Species:Human
Target:BCL2L2
Synonyms:B-Cell Lymphoma Protein 2, BCL2 Like 2, BCL2 Like protein 2, BCLW, Bcl2-L-2, Apoptosis regulator Bcl-W, BCL2L2, BCL-W, KIAA0271.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:The BCL2L2 protein solution contains 20mM Tris-HCl, pH-8, 100mM NaCl and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MATPASAPDT RALVADFVGY KLRQKGYVCG AGPGEGPAAD PLHQAMRAAG DEFETRFRRT FSDLAAQLHV TPGSAQQRFT QVSDELFQGG PNWGRLVAFF VFGAALCAES VNKEMEPLVG QVQEWMVAYL ETRLADWIHS SGGWAEFTAL YGDGALEEAR RLREGNWASV RT

BCL2L2 promotes cell survival and blocks dexamethasone-induced apoptosis. BCL2L2 mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX. BCL2L2 is part of the BCL-2 protein family which form hetero- or homodimers and play an important role as anti and proapoptotic regulators. BCL2L2 causes reduced cell apoptosis under cytotoxic conditions. BCL2L2 is involved in the survival of NGF- and BDNF-dependent neurons. BCL2L2 plays an important role in adult spermatogenesis.

BCL2L2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 192 amino acids (1-172 a.a.) and having a molecular weight of 20.9kDa.The BCL2L2 is fused to a 20 a.a His-Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.
NCBI Summary:This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]
UniProt Code:Q92843
NCBI GenInfo Identifier:296434404
NCBI Gene ID:599
NCBI Accession:Q92843.2
UniProt Secondary Accession:Q92843,Q2M3U0, Q5U0H4, A8K0F4,
UniProt Related Accession:Q92843
Molecular Weight:37,171 Da
NCBI Full Name:Bcl-2-like protein 2
NCBI Synonym Full Names:BCL2 like 2
NCBI Official Symbol:BCL2L2  
NCBI Official Synonym Symbols:BCLW; BCL-W; PPP1R51; BCL2-L-2  
NCBI Protein Information:bcl-2-like protein 2
UniProt Protein Name:Bcl-2-like protein 2
UniProt Synonym Protein Names:Apoptosis regulator Bcl-W
Protein Family:Bcl-2-like protein
UniProt Gene Name:BCL2L2  
UniProt Entry Name:B2CL2_HUMAN
View AllClose

Related Products