Human BCAS2 Recombinant Protein (RPPB2858)

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SKU:
RPPB2858
Product type:
Recombinant Protein
Size:
5ug
Species:
Human
Target:
BCAS2
Synonyms:
Pre-mRNA-splicing factor SPF27
Synonyms:
Breast carcinoma-amplified sequence 2
Synonyms:
DNA amplified in mammary carcinoma 1 protein
Synonyms:
Spliceosome-associated protein SPF 27
Source:
Escherichia Coli
Uniprot:
O75934
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Description

Product Name:Human BCAS2 Recombinant Protein
Product Code:RPPB2858
Size:5µg
Species:Human
Target:BCAS2
Synonyms:Pre-mRNA-splicing factor SPF27, Breast carcinoma-amplified sequence 2, DNA amplified in mammary carcinoma 1 protein, Spliceosome-associated protein SPF 27, BCAS2, DAM1, SPF27, Snt309.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The BCAS2 solution (0.25 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 20% glycerol, 5mM DTT and 0.2M NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMAGT GLVAGEVVVD ALPYFDQGYE APGVREAAAA LVEEETRRYR PTKNYLSYLT APDYSAFETD IMRNEFERLA ARQPIELLSM KRYELPAPSS GQKNDITAWQ ECVNNSMAQL EHQAVRIENL ELMSQHGCNA WKVYNENLVH MIEHAQKELQ KLRKHIQDLN WQRKNMQLTA GSKLREMESN WVSLVSKNYE IERTIVQLEN EIYQIKQQHG EANKENIRQD F

Pre-mRNA-splicing factor SPF27 (BCAS2) is a ubiquitously expressed nuclear protein that was initially identified as being overexpressed in various breast cancer cell lines. BCAS2 is currently as a component of the spliceosome, participating in the exclusion of introns from mRNA precursors. BCAS2 acts as an ER co-activator and is capable of boosting ER-mediated transcription, suggesting that BCAS2 is involved in the development of breast cancer.

BCAS2 Human Recombinant fused with a 36 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 261 amino acids (1-225 a.a.) and having a molecular mass of 30.3kDa. The BCAS2 is purified by proprietary chromatographic techniques.

UniProt Protein Function:BCAS2: Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Belongs to the SPF27 family.
UniProt Protein Details:

Protein type:Nucleolus; RNA splicing; Spliceosome; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 1p13.2

Cellular Component: nucleoplasm; spliceosome; DNA replication factor A complex; nucleolus; nucleus; cell junction

Molecular Function:protein binding

Biological Process: nuclear mRNA splicing, via spliceosome; RNA splicing, via transesterification reactions; RNA splicing; gene expression

UniProt Code:O75934
NCBI GenInfo Identifier:71153839
NCBI Gene ID:10286
NCBI Accession:O75934.1
UniProt Secondary Accession:O75934,Q6FGS0,
UniProt Related Accession:O75934
Molecular Weight:225
NCBI Full Name:Pre-mRNA-splicing factor SPF27
NCBI Synonym Full Names:breast carcinoma amplified sequence 2
NCBI Official Symbol:BCAS2  
NCBI Official Synonym Symbols:DAM1; SPF27; Snt309  
NCBI Protein Information:pre-mRNA-splicing factor SPF27; breast carcinoma-amplified sequence 2; spliceosome-associated protein SPF 27; DNA amplified in mammary carcinoma 1 protein; spliceosome associated protein, amplified in breast cancer
UniProt Protein Name:Pre-mRNA-splicing factor SPF27
UniProt Synonym Protein Names:Breast carcinoma-amplified sequence 2; DNA amplified in mammary carcinoma 1 protein; Spliceosome-associated protein SPF 27
UniProt Gene Name:BCAS2  
UniProt Entry Name:SPF27_HUMAN
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