Human BATF Recombinant Protein (RPPB2852)
- SKU:
- RPPB2852
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- BATF
- Synonyms:
- Basic leucine zipper transcriptional factor ATF-like
- B-cell-activating transcription factor
- B-ATF
- SF-HT-activated gene 2 protein
- Source:
- Escherichia Coli
- Uniprot:
- Q16520
Description
| Product Name: | Human BATF Recombinant Protein |
| Product Code: | RPPB2852 |
| Size: | 20µg |
| Species: | Human |
| Target: | BATF |
| Synonyms: | Basic leucine zipper transcriptional factor ATF-like, B-cell-activating transcription factor, B-ATF, SF-HT-activated gene 2 protein, SFA-2, BATF, SFA2, BATF1. |
| Source: | Escherichia Coli |
| Physical Appearance: | BATF is supplied as a sterile filtered colorless solution. |
| Formulation: | The BATF solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 0.2M NaCl, 2mM DTT and 40% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | BATF purity was found to be greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MPHSSDSSDS SFSRSPPPGK QDSSDDVRRV QRREKNRIAA QKSRQRQTQK ADTLHLESED LEKQNAALRK EIKQLTEELK YFTSVLNSHE PLCSVLAAST PSPPEVVYSA HAFHQPHVSS PRFQP |
BATF is a nuclear basic leucine zipper protein which is a member of the AP-1/ATF superfamily of transcription factors. BATF is intensely expressed in mature T and B lymphocytes, and is up-regulated after transformation by human T-cell leukemia virus type I. BATF acts as a tissue-specific modulator of the AP-1 transcription complex in human cells. Furthermore, BATF connects with IFP35 which is a leucine zipper protein that translocates to the nucleus following IFN treatment.
BATF Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 145 amino acids (1-125 a.a.) and having a molecular mass of 16.2kDa. The BATF is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | BATF: a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. Functions as a negative regulator of AP-1 mediated transcription by binding to Jun proteins. Jun/B-ATF heterodimers bind DNA preferentially at the 12-O-tetradecanoylphorbol-13- acetate response element (TRE) and weaker at the cAMP responsive region (CRE), but are transcriptionally inert. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 14q24.3 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding; sequence-specific DNA binding; transcription factor activity Biological Process: cytokine production; defense response to protozoan; DNA damage response, signal transduction by p53 class mediator; isotype switching; lymphoid progenitor cell differentiation; myeloid dendritic cell differentiation; response to DNA damage stimulus; T-helper 2 cell differentiation |
| NCBI Summary: | The protein encoded by this gene is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q16520 |
| NCBI GenInfo Identifier: | 32171340 |
| NCBI Gene ID: | 10538 |
| NCBI Accession: | Q16520.1 |
| UniProt Related Accession: | Q16520 |
| Molecular Weight: | 14,120 Da |
| NCBI Full Name: | Basic leucine zipper transcriptional factor ATF-like |
| NCBI Synonym Full Names: | basic leucine zipper ATF-like transcription factor |
| NCBI Official Symbol: | BATF |
| NCBI Official Synonym Symbols: | SFA2; B-ATF; BATF1; SFA-2 |
| NCBI Protein Information: | basic leucine zipper transcriptional factor ATF-like |
| UniProt Protein Name: | Basic leucine zipper transcriptional factor ATF-like |
| UniProt Synonym Protein Names: | B-cell-activating transcription factor; B-ATF; SF-HT-activated gene 2 protein; SFA-2 |
| Protein Family: | Basic leucine zipper transcriptional factor |
| UniProt Gene Name: | BATF |
| UniProt Entry Name: | BATF_HUMAN |
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