Human BAG1 Recombinant Protein (RPPB2847)

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SKU:
RPPB2847
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
BAG1
Synonyms:
BAG-1
Synonyms:
Bcl-2-associated athanogene 1
Synonyms:
RAP46
Synonyms:
Bcl-2-binding protein
Source:
Escherichia Coli
Uniprot:
Q99933
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Description

Product Name:Human BAG1 Recombinant Protein
Product Code:RPPB2847
Size:20µg
Species:Human
Target:BAG1
Synonyms:BAG-1, Bcl-2-associated athanogene 1, RAP46, Bcl-2-binding protein, HAP.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:BAG1 Human solution containing 20mM Tris-HCl pH-7.5, 0.1M NaCl and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MNRSQEVTRD EESTRSEEVT REEMAAAGLT VTVTHSNEKH DLHVTSQQGS SEPVVQDLAQ VVEEVIGVPQ SFQKLIFKGK SLKEMETPLS ALGIQDGCRV MLIGKKNSPQ EEVELKKLKH LEKSVEKIAD QLEELNKELT GIQQGFLPKD LQAEALCKLD RRVKATIEQF MKILEEIDTL ILPENFKDSR LKRKGLVKKV QAFLAECDTV EQNICQETER LQSTNFALAE

BAG1 binds to BCL2 and is also called BCL2-associated athanogene. BAG1 increases the anti-apoptotic effects of BCL2 and is characterizes as a link between growth factor receptors and anti-apoptotic mechanisms. BAG1 inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. BAG1 inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. BAG1 enhances the anti-cell death function of BCL2 induced by various stimuli.

BAG1 Human Recombinant produced in E.Coli is a single, non-glycosylated,polypeptide chain containing 230 amino acids (1-230 a.a.) and having a molecular mass of 25.9 kDa. BAG1 protein is purified by standard chromatography.

UniProt Protein Function:BAG1: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli. Homodimer. Forms a heteromeric complex with HSP70/HSC70. Binds to the ATPase domain of HSP/HSC70 chaperones. Isoform 1, isoform 3 and isoform 4 but not isoform 2 interact with HSPA8/HSC70. Interacts with NR3C1. Interacts with the N-terminal region of STK19. Interacts with PPP1R15A. Interacts with BCL2 in an ATP-dependent manner. Isoform 2 does not interact with BCL2. Up-regulated during differentiation of bladder epithelial cells and down-regulated during differentiation of prostate epithelium. Isoform 4 is the most abundantly expressed isoform. It is ubiquitously expressed throughout most tissues, except the liver, colon, breast and uterine myometrium. Isoform 1 is expressed in the ovary and testis. Isoform 4 is expressed in several types of tumor cell lines, and at consistently high levels in leukemia and lymphoma cell lines. Isoform 1 is expressed in the prostate, breast and leukemia cell lines. Isoform 3 is the least abundant isoform in tumor cell lines. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Nuclear receptor co-regulator; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9p12

Cellular Component: cytoplasm; nucleus

Molecular Function:protein binding; chaperone binding; receptor signaling protein activity

Biological Process: cell surface receptor linked signal transduction; apoptosis; negative regulation of apoptosis

NCBI Summary:The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X. [provided by RefSeq, Feb 2010]
UniProt Code:Q99933
NCBI GenInfo Identifier:296439462
NCBI Gene ID:573
NCBI Accession:Q99933.4
UniProt Secondary Accession:Q99933,O75315, Q14414, Q53H32, Q5VZE8, Q5VZE9, Q5VZF0 Q96TG2, Q9Y2V4,
UniProt Related Accession:Q99933
Molecular Weight:345
NCBI Full Name:BAG family molecular chaperone regulator 1
NCBI Synonym Full Names:BCL2-associated athanogene
NCBI Official Symbol:BAG1  
NCBI Official Synonym Symbols:HAP; BAG-1; RAP46  
NCBI Protein Information:BAG family molecular chaperone regulator 1; Bcl-2-binding protein; receptor-associated protein, 46-KD; Bcl-2 associating athanogene-1 protein; glucocortoid receptor-associated protein RAP46
UniProt Protein Name:BAG family molecular chaperone regulator 1
UniProt Synonym Protein Names:Bcl-2-associated athanogene 1
Protein Family:BAG family molecular chaperone regulator
UniProt Gene Name:BAG1  
UniProt Entry Name:BAG1_HUMAN
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