Human ATP1B1 Recombinant Protein (RPPB2818)

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SKU:
RPPB2818
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
ATP1B1
Synonyms:
Sodium/potassium-transporting ATPase subunit beta-1
Synonyms:
ATPase
Synonyms:
Na+/K+ transporting
Synonyms:
beta 1 polypeptide
Source:
Escherichia Coli
Uniprot:
P05026
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Description

Product Name:Human ATP1B1 Recombinant Protein
Product Code:RPPB2818
Size:20µg
Species:Human
Target:ATP1B1
Synonyms:Sodium/potassium-transporting ATPase subunit beta-1, ATPase, Na+/K+ transporting, beta 1 polypeptide, ATP1B, ATPBS, Sodium/potassium-dependent ATPase subunit beta-1, ATP1B1, ATPaseTransporting Beta 1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The ATP1B1 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M Urea.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSEFKPTYQ DRVAPPGLTQ IPQIQKTEIS FRPNDPKSYE AYVLNIVRFL EKYKDSAQRD DMIFEDCGDV PSEPKERGDF NHERGERKVC RFKLEWLGNC SGLNDETYGY KEGKPCIIIK LNRVLGFKPK PPKNESLETY PVMKYNPNVL PVQCTGKRDE DKDKVGNVEY FGLGNSPGFP LQYYPYYGKL LQPKYLQPLL AVQFTNLTMD TEIRIECKAY GENIGYSEKD RFQGRFDVKI EVKS

ATPaseTransporting Beta 1 (ATP1B1) is a part of the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an essential membrane protein accountable for establishing and maintaining the electrochemical gradients of Na and K ions over the plasma membrane. These gradients are vital for osmoregulation, for sodium-coupled transport of a range of organic and inorganic molecules, and for electrical excitability of muscle and nerve. ATP1B1is combined of 2 subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates the number of sodium pumps transported to the plasma membrane through assembly of alpha/beta heterodimers. ATP1B1 is a beta 1 subunit.

ATP1B1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 264 amino acids (63-303) and having a molecular mass of 30.4 kDa.ATP1B1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:ATP1B1: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transporter; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q24

Cellular Component: apical plasma membrane; basolateral plasma membrane; caveola; intracellular; membrane; myelin sheath; plasma membrane; sarcolemma; sodium:potassium-exchanging ATPase complex

Molecular Function:ATP binding; ATPase activator activity; ATPase activity; ATPase binding; drug binding; potassium ion binding; protein binding; protein C-terminus binding; sodium ion binding; sodium:potassium-exchanging ATPase activity

Biological Process: ATP metabolic process; blood coagulation; cardiac muscle contraction; cell adhesion; cellular calcium ion homeostasis; cellular potassium ion homeostasis; cellular sodium ion homeostasis; establishment and/or maintenance of transmembrane electrochemical gradient; leukocyte migration; positive regulation of ATPase activity; positive regulation of defense response to virus by host; potassium ion import; protein stabilization; regulation of gene expression; response to hypoxia; transmembrane transport

Disease: Hypertension, Essential

NCBI Summary:The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known. [provided by RefSeq, Mar 2010]
UniProt Code:P05026
NCBI GenInfo Identifier:114392
NCBI Gene ID:481
NCBI Accession:P05026.1
UniProt Secondary Accession:P05026,Q5TGZ3,
UniProt Related Accession:P05026
Molecular Weight:34,893 Da
NCBI Full Name:Sodium/potassium-transporting ATPase subunit beta-1
NCBI Synonym Full Names:ATPase Na+/K+ transporting subunit beta 1
NCBI Official Symbol:ATP1B1  
NCBI Official Synonym Symbols:ATP1B  
NCBI Protein Information:sodium/potassium-transporting ATPase subunit beta-1
UniProt Protein Name:Sodium/potassium-transporting ATPase subunit beta-1
UniProt Synonym Protein Names:Sodium/potassium-dependent ATPase subunit beta-1
UniProt Gene Name:ATP1B1  
UniProt Entry Name:AT1B1_HUMAN
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