Human ASNA1 Recombinant Protein (RPPB2808)

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SKU:
RPPB2808
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
ASNA1
Synonyms:
ArsA Arsenite Transporter ATP-Binding Homolog 1 (Bacterial)
Synonyms:
Arsenical Pump-Driving ATPase
Synonyms:
Transmembrane Domain Recognition Complex 40kDa
Synonyms:
TRC40 ASNA-I
Source:
Escherichia Coli
Uniprot:
O43681
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Description

Product Name:Human ASNA1 Recombinant Protein
Product Code:RPPB2808
Size:20µg
Species:Human
Target:ASNA1
Synonyms:ArsA Arsenite Transporter ATP-Binding Homolog 1 (Bacterial), Arsenical Pump-Driving ATPase, Transmembrane Domain Recognition Complex 40kDa, TRC40. ASNA-I, ATPase ASNA1, ARSA-I, GET3, Golgi To ER Traffic 3 Homolog, Arsenite-Stimulated ATPase, Transmembrane Domain Recognition Complex 40 KDa ATPase Subunit, HASNA-I, HARSA-I, ARSA, ARSA1, EC 3.6.3.16, EC 3.6.-.-.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The ASNA1 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMAAGVAG WGVEAEEFED APDVEPLEPT LSNIIEQRSL KWIFVGGKGG VGKTTCSCSL AVQLSKGRES VLIISTDPAH NISDAFDQKF SKVPTKVKGY DNLFAMEIDP SLGVAELPDE FFEEDNMLSM GKKMMQEAMS AFPGIDEAMS YAEVMRLVKG MNFSVVVFDT APTGHTLRLL NFPTIVERGL GRLMQIKNQI SPFISQMCNM LGLGDMNADQ LASKLEETLP VIRSVSEQFK DPEQTTFICV CIAEFLSLYE TERLIQELAK CKIDTHNIIV NQLVFPDPEK PCKMCEARHK IQAKYLDQME DLYEDFHIVK LPLLPHEVRG ADKVNTFSAL LLEPYKPPSA Q

ArsA Arsenite Transporter, ATP-Binding, Homolog 1 (ASNA1) is a part of the arsA ATPase family. ASNA1 is the human homolog of the bacterial arsA gene. ArsA ATPase is the catalytic component of a multisubunit oxyanion pump In E.coli, which is in charge for resistance to arsenicals and antimonials. ASNA1 is also a main component of a transmembrane domain (TMD) recognition complex (TRC) which is involved in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER).

ASNA1 Human Recombinant produced in E. coli is a single polypeptide chain containing 371 amino acids (1-348) and having a molecular mass of 41.2 kDa. ASNA1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:ASNA1: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting. May be involved in insulin signaling. Belongs to the arsA ATPase family.
UniProt Protein Details:

Protein type:Nucleolus; EC 3.6.-.-; EC 3.6.3.16; Hydrolase

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: endoplasmic reticulum; cytoplasm; nucleolus; nucleus

Molecular Function:arsenite transmembrane transporter activity; transporter activity; metal ion binding; ATPase activity; ATP binding

Biological Process: protein insertion into ER membrane; transport; metabolic process; inorganic anion transport

NCBI Summary:This gene represents the human homolog of the bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to arsenicals. This protein is also a central component of a transmembrane domain (TMD) recognition complex (TRC) that is involved in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER). It recognizes and selectively binds the TMD of TA proteins in the cytosol, and delivers them to the ER for insertion. [provided by RefSeq, Oct 2011]
UniProt Code:O43681
NCBI GenInfo Identifier:6647417
NCBI Gene ID:439
NCBI Accession:O43681.2
UniProt Secondary Accession:O43681,Q53FC6, Q92849, A6NHP8, A8K740,
UniProt Related Accession:O43681
Molecular Weight:Calculated: 38kDaObserved: 39kDa
NCBI Full Name:ATPase ASNA1
NCBI Synonym Full Names:arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
NCBI Official Symbol:ASNA1  
NCBI Official Synonym Symbols:GET3; ARSA1; TRC40; ARSA-I; ASNA-I; hASNA-I  
NCBI Protein Information:ATPase ASNA1; golgi to ER traffic 3 homolog; transmembrane domain recognition complex, 40kDa; transmembrane domain recognition complex 40 kDa ATPase subunit
UniProt Protein Name:ATPase ASNA1
UniProt Synonym Protein Names:Arsenical pump-driving ATPase; Arsenite-stimulated ATPase
Protein Family:ATPase
UniProt Gene Name:ASNA1  
UniProt Entry Name:ASNA_HUMAN
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