Human ART4 Recombinant Protein (RPPB1415)

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SKU:
RPPB1415
Product type:
Recombinant Protein
Size:
5ug
Species:
Human
Target:
ART4
Synonyms:
ARTC4
Synonyms:
DOK1
Synonyms:
CD297 Antigen
Synonyms:
Dombrock Blood Group
Source:
Sf9 Insect cells
Uniprot:
Q93070
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Description

Product Name:Human ART4 Recombinant Protein
Product Code:RPPB1415
Size:5µg
Species:Human
Target:ART4
Synonyms:ARTC4, DOK1, CD297 Antigen, Dombrock Blood Group, ADP-Ribosyltransferase 4, Ecto-ADP-Ribosyltransferase 4.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:ART4 protein solution (0.25mg/ml) contains Buffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:ADPSEVAIKI DFDFAPGSFD DQYQGCSKQV MEKLTQGDYF TKDIEAQKNY FRMWQKAHLA WLNQGKVLPQ NMTTTHAVAI LFYTLNSNVH SDFTRAMASV ARTPQQYERS FHFKYLHYYL TSAIQLLRKD SIMENGTLCY EVHYRTKDVH FNAYTGATIR FGQFLSTSLL KEEAQEFGNQ TLFTIFTCLG APVQYFSLKK EVLIPPYELF KVINMSYHPR GDWLQLRSTG NLSTYNCQLL KAHHHHHH

Ecto-ADP-Ribosyltransferase 4 or ART4 is typed as a glycosylphosphatidylinositol (GPI)-linked membrane protein which carries Dombrock blood group antigens. The development of this protein takes place at the highest levels in the fetal liver.  the process of the ART4 development is regulated while the erythroid differentiation process occurs. ART4 is a is part of the Ribosyltransferase family.

ART4 produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 248 amino acids (47-285 a.a.) and having a molecular mass of 28.8kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa). ART4 is expressed with a 9 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

NCBI Summary:This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known. [provided by RefSeq, Jul 2008]
UniProt Code:Q93070
NCBI GenInfo Identifier:22261809
NCBI Gene ID:420
NCBI Accession:Q93070.2
UniProt Related Accession:Q93070
Molecular Weight:36kDa
NCBI Full Name:Ecto-ADP-ribosyltransferase 4
NCBI Synonym Full Names:ADP-ribosyltransferase 4 (Dombrock blood group)
NCBI Official Symbol:ART4  
NCBI Official Synonym Symbols:DO; DOK1; ARTC4; CD297; DO/ART4  
NCBI Protein Information:ecto-ADP-ribosyltransferase 4
UniProt Protein Name:Ecto-ADP-ribosyltransferase 4
UniProt Synonym Protein Names:ADP-ribosyltransferase C2 and C3 toxin-like 4; ARTC4; Dombrock blood group carrier molecule; Mono(ADP-ribosyl)transferase 4; NAD(P)(+)--arginine ADP-ribosyltransferase 4; CD_antigen: CD297
Protein Family:Ecto-ADP-ribosyltransferase
UniProt Gene Name:ART4  
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