Human ARL11 Recombinant Protein (RPPB2784)
- SKU:
- RPPB2784
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- ARL11
- Synonyms:
- ADP-ribosylation factor-like protein 11
- ADP-ribosylation factor-like tumor suppressor protein 1
- ARL11
- ARLTS1
- Source:
- Escherichia Coli
- Uniprot:
- Q969Q4
Description
| Product Name: | Human ARL11 Recombinant Protein |
| Product Code: | RPPB2784 |
| Size: | 20µg |
| Species: | Human |
| Target: | ARL11 |
| Synonyms: | ADP-ribosylation factor-like protein 11, ADP-ribosylation factor-like tumor suppressor protein 1, ARL11, ARLTS1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | ARL11 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 5mM DTT,30% glycerol, 100mM NaCl and 1mM EDTA. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSVNSRGHK AEAQVVMMGL DSAGKTTLLY KLKGHQLVET LPTVGFNVEP LKAPGHVSLT LWDVGGQAPL RASWKDYLEG TDILVYVLDS TDEARLPESA AELTEVLNDP NMAGVPFLVL ANKQEAPDAL PLLKIRNRLS LERFQDHCWE LRGCSALTGE GLPEALQSLW SLLKSRSCMC LQARAHGAER GDSKRS |
ARL11 (ADP-ribosylation factor-like protein 11) belongs to the ARF family of the Ras superfamily of small GTPases which are known to be involved in multiple regulatory pathways altered in human carcinogenesis. ARFs are highly conserved guanine nucleotide binding proteins which enhance the ADP-ribosyltransferase activity of choleratoxin. ARFs are important in eukaryotic vesicular trafficking pathways and they have a vital role in the activation of phospholipase D (PC-PLD). ARL11 is assumed to act as a tumor suppressor which may have a role in the regulation of apoptosis.
ARL11 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 216 amino acids (1-196 a.a.) and having a molecular mass of 23.6kDa.ARL11 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | May play a role in apoptosis. May act as a tumor suppressor. |
| NCBI Summary: | This gene encodes a tumor suppressor related to the ADP-ribosylation factor (ARF) family of proteins. The encoded protein may play a role in apoptosis in a caspase-dependent manner. Polymorphisms in this gene have been associated with some familial cancers. [provided by RefSeq, May 2010] |
| UniProt Code: | Q969Q4 |
| NCBI GenInfo Identifier: | 19923979 |
| NCBI Gene ID: | 115761 |
| NCBI Accession: | NP_612459.1 |
| UniProt Related Accession: | Q969Q4 |
| Molecular Weight: | 21,391 Da |
| NCBI Full Name: | ADP-ribosylation factor-like protein 11 |
| NCBI Synonym Full Names: | ADP ribosylation factor like GTPase 11 |
| NCBI Official Symbol: | ARL11 |
| NCBI Official Synonym Symbols: | ARLTS1 |
| NCBI Protein Information: | ADP-ribosylation factor-like protein 11 |
| UniProt Protein Name: | ADP-ribosylation factor-like protein 11 |
| UniProt Synonym Protein Names: | ADP-ribosylation factor-like tumor suppressor protein 1 |
| Protein Family: | ADP-ribosylation factor-like protein |
| UniProt Gene Name: | ARL11 |
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