Human ARG1 Recombinant Protein (RPPB1407)

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SKU:
RPPB1407
Product type:
Recombinant Protein
Size:
25ug
Species:
Human
Target:
ARG1
Synonyms:
EC 3531
Synonyms:
Arginase 1
Synonyms:
Type I Arginase
Synonyms:
Liver-Type Arginase
Source:
Escherichia Coli
Uniprot:
P05089
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Description

Product Name:Human ARG1 Recombinant Protein
Product Code:RPPB1407
Size:25µg
Species:Human
Target:ARG1
Synonyms:EC 3.5.3.1, Arginase 1, Type I Arginase, Liver-Type Arginase.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:ARG1 Human protein solution (0.5mg/ml) containing 20mM Tris-HCl pH-8, 2mM DTT, 0.1M NaCl & 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MSAKSRTIGI IGAPFSKGQP RGGVEEGPTV LRKAGLLEKL KEQECDVKDY GDLPFADIPN DSPFQIVKNP RSVGKASEQL AGKVAEVKKN GRISLVLGGD HSLAIGSISG HARVHPDLGV IWVDAHTDIN TPLTTTSGNL HGQPVSFLLK ELKGKIPDVP GFSWVTPCIS AKDIVYIGLR DVDPGEHYIL KTLGIKYFSM TEVDRLGIGK VMEETLSYLL GRKKRPIHLS FDVDGLDPSF TPATGTPVVG GLTYREGLYI TEEIYKTGLL SGLDIMEVNP SLGKTPEEVT RTVNTAVAIT LACFGLAREG NHKPIDYLNP PKLEHHHHHH

ARG1 catalyzes the hydrolysis of arginine to ornithine and urea. 2 isoforms of mammalian arginase exist which vary in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic role. ARG1 is a cytosolic enzyme and expressed widely in the liver as part of the urea cycle. Inherited deficiency of this ARG1 causes argininemia, which is an autosomal recessive disorder characterized by hyperammonemia.

ARG1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 330 amino acids (1-322a.a.) and having a molecular mass of 35.8kDa. ARG1 protein is fused to an 8 amino acid His tag at C-terminus and is purified by standard chromatography.

UniProt Protein Function:ARG1: Homotrimer. By arginine or homoarginine. Belongs to the arginase family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Amino Acid Metabolism - arginine and proline; EC 3.5.3.1; Hydrolase

Chromosomal Location of Human Ortholog: 6q23.2

Cellular Component: cytoplasm; cytosol; extracellular region; nucleus

Molecular Function:arginase activity

Biological Process: arginine catabolic process; neutrophil degranulation; urea cycle

Disease: Argininemia

NCBI Summary:Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
UniProt Code:P05089
NCBI GenInfo Identifier:12230985
NCBI Gene ID:383
NCBI Accession:P05089.2
UniProt Secondary Accession:P05089,Q5JWT5, Q5JWT6, Q8TE72, Q9BS50, A6NEA0,
UniProt Related Accession:P05089
Molecular Weight:35kDa
NCBI Full Name:Arginase-1
NCBI Synonym Full Names:arginase 1
NCBI Official Symbol:ARG1  
NCBI Protein Information:arginase-1
UniProt Protein Name:Arginase-1
UniProt Synonym Protein Names:Liver-type arginase; Type I arginase
Protein Family:Arginase
UniProt Gene Name:ARG1  
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