Human APE1/APE Recombinant Protein (RPES2965)

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SKU:
RPES2965
Product type:
Recombinant Protein
Host species:
E.coli
Reactivity:
Human
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Description

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Human APE1/APE Recombinant Protein

Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases; APE1 cleaves the AP site to allow resynthesis and ligation to complete repair. APE1 stimulates the DNA binding activity of many transcription factors; which participate in cancer promotion and progression. APE1 regulates the redox state of multiple transcription factors; such as c-Jun; c-Fos; NF-kB; p53. APEN is also involved in calcium-dependent down-regulation of PTH expression.

Product Name:Human APE1/APE Recombinant Protein (RPES2965)
Product Code:RPES2965
Size:10µg
Species:Human
Expressed Host:E.coli
Synonyms:DNA-(Apurinic or Apyrimidinic Site) Lyase, APEX Nuclease, APEN, Apurinic-Apyrimidinic Endonuclease 1, AP Endonuclease 1, APE-1REF-1, Redox Factor-1, APEX1, APE, APE1, APEX, APX, HAP1, REF1
Accession:P27695
Sequence:Pro2-Leu318
Fusion tag:
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human Apurinic-Apyrimidinic Endonuclease 1 is produced by our E.coli expression system and the target gene encoding Pro2-Leu318 is expressed.
Purity:> 95 % as determined by reducing SDS-PAGE.
Mol Mass:35.6 kDa
AP Mol Mass:40 kDa
Formulation:Supplied as a 0.2 µm filtered solution of 10mM HEPES; 100mM KCl; 50% Glycerol; pH 7.4.
Shipping:This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C.
Stability and Storage:Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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