Human ANXA8L1 Recombinant Protein (RPPB2760)

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SKU:
RPPB2760
Product type:
Recombinant Protein
Size:
5ug
Species:
Human
Target:
ANXA8L1
Synonyms:
Annexin A8-like protein 2
Synonyms:
bA145E202
Synonyms:
ANXA8
Synonyms:
annexin A8L2
Source:
Escherichia Coli
Uniprot:
Q5VT79
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Description

Product Name:Human ANXA8L1 Recombinant Protein
Product Code:RPPB2760
Size:5µg
Species:Human
Target:ANXA8L1
Synonyms:Annexin A8-like protein 2, bA145E20.2, ANXA8, annexin A8L2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The ANXA8L1 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 1mM DTT and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMAWWKA WIEQEGVTVK SSSHFNPDPD AETLYKAMKG IGTNEQAIID VLTKRSNTQR QQIAKSFKAQ FGKDLTETLK SELSGKFERL IVALMYPPYR YEAKELHDAM KGLGTKEGVI IEILASRTKN QLREIMKAYE EDYGSSLEED IQADTSGYLE RILVCLLQGS RDDVSSFVDP ALALQDAQDL YAAGENIRGT DEMKFITILC TRSATHLLRV FEEYEKIANK SIEDSIKSET HGSLEEAMLT VVKCTQNLHS YFAERLYYAM KGAGTRDGTL IRNIVSRSEI DLNLIKCHFK KMYGKTLSSM IMEDTSGDYK NALLSLVGSD P

Annexin A8-like 2 (ANXA8L2) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Annexin family members are regulators of such varied processes such as ion flux, endocytosis and exocytosis, and cellular adhesion. ANXA8L2 is a membrane binding protein with various properties, including voltage-sensitive calcium channel activity, ion selectivity and membrane fusion. ANXA8L2 overexpressionis linked to acute myelocytic leukemia. ANXA8L2 may act as an anticoagulant which indirectly inhibits the thromboplastin-specific complex.

ANXA8L1 Human Recombinant produced in E. coli is a single polypeptide chain containing 351 amino acids (1-327) and having a molecular mass of 39.4 kDa.ANXA8L1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:ANXA8L1: Belongs to the annexin family.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 10q11.22

Molecular Function:calcium-dependent phospholipid binding; calcium ion binding

NCBI Summary:This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10. [provided by RefSeq, Apr 2014]
UniProt Code:Q5VT79
NCBI GenInfo Identifier:524552373
NCBI Gene ID:728113
NCBI Accession:NP_001092315.2
UniProt Secondary Accession:Q5VT79,Q53FY2, Q5VT78, Q96H89, B2R939,
UniProt Related Accession:Q5T2P8
Molecular Weight:30,677 Da
NCBI Full Name:annexin A8-like protein 1 isoform 1
NCBI Synonym Full Names:annexin A8-like 1
NCBI Official Symbol:ANXA8L1  
NCBI Official Synonym Symbols:ANXA8; ANXA8L2; VAC-beta; bA145E20.2  
NCBI Protein Information:annexin A8-like protein 1; annexin A8-like protein 2; annexin A8L2; annexin VIII; annexin-8; vascular anticoagulant-beta
UniProt Protein Name:Annexin A8-like protein 2
UniProt Gene Name:ANXA8L2  
UniProt Entry Name:AXA82_HUMAN
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