Human ANXA8 Recombinant Protein (RPPB2759)

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SKU:
RPPB2759
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
ANXA8
Synonyms:
ANX8
Synonyms:
Annexin-8
Synonyms:
Annexin VII
Synonyms:
Vascular anticoagulant-beta
Source:
Escherichia Coli
Uniprot:
P13928
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Description

Product Name:Human ANXA8 Recombinant Protein
Product Code:RPPB2759
Size:20µg
Species:Human
Target:ANXA8
Synonyms:ANX8, Annexin-8, Annexin VII, Vascular anticoagulant-beta, VAC-beta.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless clear solution.
Formulation:The ANXA8 1mg/ml protein solution contains 20mM Tris-HCL pH-8, 1mM DTT,1mM EDTA, 0.1M NaCl and 10% Glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MAWWKSWIEQ EGVTVKSSSH FNPDPDAETL YKAMKGIGTN EQAIIDVLTK RSNTQRQQIA KSFKAQFGKD LTETLKSELS GKFERLIVAL MYPPYRYEAK ELHDAMKGLG TKEGVIIEIL ASRTKNQLRE IMKAYEEDYG SSLEEDIQAD TSGYLERILV CLLQGSRDDV SSFVDPGLAL QDAQDLYAAG EKIRGTDEMK FITILCTRSA THLLRVFEEY EKIANKSIED SIKSETHGSL EEAMLTVVKC TQNLHSYFAE RLYYAMKGAG TRDGTLIRNI VSRSEIDLNL IKCHFKKMYG KTLSSMIMED TSGDYKNALL SLVGSDP

ANXA8 is part of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. ANXA8 is an anticoagulant protein that functions as an indirect inhibitor of the thromboplastin-specific complex, which takes part in the blood coagulation cascade. Where co-expressed in the same tissues, ANXA8 is expressed at a 100-fold lower level than Annexin A5. Though, ANXA8 is preferentially expressed in acute promyelocytic leukemia (APL) cells which suggests its involvement in hematopoietic cell differentiation.

ANXA8 Human Recombinant produced in E.Coli is a signle, non-glycosylated, polypeptide chain containing 347 amino acids (1-327 a.a.)and having a total molecular mass of 39 kDa. ANXA8 is fused to a 20 amino acid His Tag at N-terminus and is purified by proprietary chromatographic techniques.

UniProt Protein Function:ANXA8: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Belongs to the annexin family.Chromosomal Location of Human Ortholog: 10q11.22Cellular Component: late endosome membrane; plasma membrane; cytosolMolecular Function: actin filament binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylinositol-3,4,5-triphosphate binding; calcium-dependent phospholipid binding; calcium ion binding; phosphatidylinositol-3,4-bisphosphate bindingBiological Process: endosome organization and biogenesis; blood coagulation; endosome transport
UniProt Protein Details:
NCBI Summary:This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10. [provided by RefSeq, Jul 2008]
UniProt Code:P13928
NCBI GenInfo Identifier:49257004
NCBI Gene ID:653145
NCBI Accession:AAH73755.1
UniProt Secondary Accession:P13928,Q5VTM4, Q6GMY3, Q9BT34, A6NLM1
UniProt Related Accession:P13928
Molecular Weight:36,881 Da
NCBI Full Name:Annexin A8
NCBI Synonym Full Names:annexin A8
NCBI Official Symbol:ANXA8  
NCBI Official Synonym Symbols:ANX8  
NCBI Protein Information:annexin A8; VAC-beta; annexin-8; annexin VIII; vascular anticoagulant-beta
UniProt Protein Name:Annexin A8
UniProt Synonym Protein Names:Annexin VIII; Annexin-8; Vascular anticoagulant-beta; VAC-beta
Protein Family:Annexin
UniProt Gene Name:ANXA8  
UniProt Entry Name:ANXA8_HUMAN
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