Human ANGPTL8/Beta-trophin Recombinant Protein (RPES2520)

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SKU:
RPES2520
Product type:
Recombinant Protein
Host species:
Human Cells
Reactivity:
Human
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Description

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Human ANGPTL8/Beta-trophin Recombinant Protein

The protein specifically promotes pancreatic beta cell proliferation and beta cell mass expansion, thereby improving glucose tolerance. It promotes pancreatic beta cell proliferation without insulin resistance. Also it acts as a blood lipid regulator by regulating serum triglyceride levels and possibly by promoting ANGPTL3 cleavage. It interacts with ANGPTL3. It predominantly expressed in liver and also expressed in adipose tissues. The ability of the protein to induce pancreatic beta cell proliferation is promising in diabetes therapy. Betatrophin treatment could supply or replace insulin injections by increasing the number of insulin-producing cells in diabetes.

Product Name:Human ANGPTL8/Beta-trophin Recombinant Protein (RPES2520)
Product Code:RPES2520
Size:10µg
Species:Human
Expressed Host:Human Cells
Synonyms:Betatrophin,Angiopoietin-like protein 8,Lipasin,Angptl8
Accession:Q6UXH0
Sequence:Ala22-Ala198
Fusion tag:N-Fc
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human Angiopoietin-like protein 8 is produced by our Mammalian expression system and the target gene encoding Ala22-Ala198 is expressed with a Fc tag at the N-terminus.
Purity:> 95 % as determined by reducing SDS-PAGE.
Mol Mass:46.0 kDa
AP Mol Mass:54 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of 20mM PB,150mM NaCl,pH7.4.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

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