Human AMN Recombinant Protein (RPPB2733)
- SKU:
- RPPB2733
- Product type:
- Recombinant Protein
- Size:
- 5ug
- Species:
- Human
- Target:
- AMN
- Synonyms:
- Protein amnionless
- AMN
- PRO1028
- amnionless
- Source:
- Escherichia Coli
- Uniprot:
- Q9BXJ7
Frequently bought together:
Description
| Product Name: | Human AMN Recombinant Protein |
| Product Code: | RPPB2733 |
| Size: | 5µg |
| Species: | Human |
| Target: | AMN |
| Synonyms: | Protein amnionless, AMN, PRO1028, amnionless. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | AMN protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSVSKLWVP NTDFDVAANW SQNRTPCAGG AVEFPADKMV SVLVQEGHAV SDMLLPLDGE LVLASGAGFG VSDVGSHLDC GAGEPAVFRD SDRFSWHDPH LWRSGDEAPG LFFVDAERVP CRHDDVFFPP SASFRVGLGP GASPVRVRSI SALGRTFTRD EDLAVFLASR AGRLRFHGPG ALSVGPEDCA DPSGCVCGNA EAQPWICAAL LQPLGGRCPQ AACHSALRPQ GQCCDLCGAV VLLTHGPAFD LERYRARILD TFLGLPQYHG LQVAVSKVPR SSRLREADTE IQVVLVENGP ETGGAGRLAR ALLADVAENG EALGVLEATM RESGAHVWGS S |
Amnion Associated Transmembrane Protein (AMN) is a type I transmembrane protein. The AMN protein is essential for efficient absorption of vitamin B12. AMN is assumed to modulate bone morphogenetic protein (BMP) receptor function by acting as an accessory or coreceptor thus facilitating or hindering BMP binding. A complex of AMN and cubilin forms the cubam receptor.
AMN Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 361 amino acids (20-357 a.a) and having a molecular mass of 38.2kDa.AMN is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Necessary for efficient absorption of vitamin B12 (PubMed:12590260, PubMed:14576052). Required for normal CUBN-mediated protein transport in the kidney. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm (). |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9BXJ7 |
| NCBI GenInfo Identifier: | 37222204 |
| NCBI Gene ID: | 81693 |
| NCBI Accession: | AAQ89949.1 |
| UniProt Secondary Accession: | Q9BXJ7,Q6UX83 |
| UniProt Related Accession: | Q9BXJ7 |
| Molecular Weight: | 47,754 Da |
| NCBI Full Name: | AMN, partial |
| NCBI Synonym Full Names: | amnion associated transmembrane protein |
| NCBI Official Symbol: | AMN |
| NCBI Official Synonym Symbols: | PRO1028; amnionless |
| NCBI Protein Information: | protein amnionless |
| UniProt Protein Name: | Protein amnionless |
| UniProt Synonym Protein Names: | |
| Protein Family: | AMP nucleosidase |
| UniProt Gene Name: | AMN |
| UniProt Entry Name: |
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