Human AMN Recombinant Protein (RPPB2733)

(No reviews yet) Write a Review

제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.

주문
SKU:
RPPB2733
Product type:
Recombinant Protein
Size:
5ug
Species:
Human
Target:
AMN
Synonyms:
Protein amnionless
Synonyms:
AMN
Synonyms:
PRO1028
Synonyms:
amnionless
Source:
Escherichia Coli
Uniprot:
Q9BXJ7
€0.00
Frequently bought together:

Description

Product Name:Human AMN Recombinant Protein
Product Code:RPPB2733
Size:5µg
Species:Human
Target:AMN
Synonyms:Protein amnionless, AMN, PRO1028, amnionless.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:AMN protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSVSKLWVP NTDFDVAANW SQNRTPCAGG AVEFPADKMV SVLVQEGHAV SDMLLPLDGE LVLASGAGFG VSDVGSHLDC GAGEPAVFRD SDRFSWHDPH LWRSGDEAPG LFFVDAERVP CRHDDVFFPP SASFRVGLGP GASPVRVRSI SALGRTFTRD EDLAVFLASR AGRLRFHGPG ALSVGPEDCA DPSGCVCGNA EAQPWICAAL LQPLGGRCPQ AACHSALRPQ GQCCDLCGAV VLLTHGPAFD LERYRARILD TFLGLPQYHG LQVAVSKVPR SSRLREADTE IQVVLVENGP ETGGAGRLAR ALLADVAENG EALGVLEATM RESGAHVWGS S

Amnion Associated Transmembrane Protein (AMN) is a type I transmembrane protein. The AMN protein is essential for efficient absorption of vitamin B12. AMN is assumed to modulate bone morphogenetic protein (BMP) receptor function by acting as an accessory or coreceptor thus facilitating or hindering BMP binding. A complex of AMN and cubilin forms the cubam receptor.

AMN Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 361 amino acids (20-357 a.a) and having a molecular mass of 38.2kDa.AMN is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Necessary for efficient absorption of vitamin B12 (PubMed:12590260, PubMed:14576052). Required for normal CUBN-mediated protein transport in the kidney. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm ().
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila. [provided by RefSeq, Jul 2008]
UniProt Code:Q9BXJ7
NCBI GenInfo Identifier:37222204
NCBI Gene ID:81693
NCBI Accession:AAQ89949.1
UniProt Secondary Accession:Q9BXJ7,Q6UX83
UniProt Related Accession:Q9BXJ7
Molecular Weight:47,754 Da
NCBI Full Name:AMN, partial
NCBI Synonym Full Names:amnion associated transmembrane protein
NCBI Official Symbol:AMN  
NCBI Official Synonym Symbols:PRO1028; amnionless  
NCBI Protein Information:protein amnionless
UniProt Protein Name:Protein amnionless
UniProt Synonym Protein Names:
Protein Family:AMP nucleosidase
UniProt Gene Name:AMN  
UniProt Entry Name:
View AllClose

Related Products