Human AMH Recombinant Protein (RPPB2730)

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SKU:
RPPB2730
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
AMH
Synonyms:
Anti-Muellerian hormone
Synonyms:
AMH
Synonyms:
Muellerian-inhibiting substance
Synonyms:
MIS
Source:
Escherichia Coli
Uniprot:
P03971
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Description

Product Name:Human AMH Recombinant Protein
Product Code:RPPB2730
Size:10µg
Species:Human
Target:AMH
Synonyms:Anti-Muellerian hormone, AMH, Muellerian-inhibiting substance, MIS, MIF.
Source:Escherichia Coli
Physical Appearance:Filtered White lyophilized (freeze-dried) powder.
Formulation:AMH filtered (0.4 µm) and lyophilized  in 1mM HCl and 5% (w/v) trehalose.
Solubility:It is recommended to add 200µl deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. AMH is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Stability:Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after one week at 4°C.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MKHHHHHHAS AGATAADGPC ALRELSVDLR AERSVLIPET YQANNCQGVC GWPQSDRNPR YGNHVVLLLK MQARGAALAR PPCCVPTAYA GKLLISLSEE RISAHHVPNM VATECGCR

Anti-Mullerian Hormone also known as AMH is a member of the TGF-beta family. AMH is a glycoprotein which is produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. AMH inhibits the growth of tumors derived from tissues of Muellerian duct origin. Moreover, AMH participates in Leydig cell differentiation and function in addition to follicular development in adult females.

AMH Human Recombinant produced in E. coli is a single, non-glycosylated polypeptide chain (a.a 452-560) containing 118 amino acids including a 9 a.a N-terminal His tag. The total molecular mass is 12.8kDa (calculated). 

UniProt Protein Function:This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin.
NCBI Summary:This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Mutations in this gene result in persistent Mullerian duct syndrome. [provided by RefSeq, Jul 2016]
UniProt Code:P03971
NCBI GenInfo Identifier:313104218
NCBI Gene ID:268
NCBI Accession:P03971.3
UniProt Secondary Accession:P03971,O75246, Q6GTN3,
UniProt Related Accession:P03971
Molecular Weight:
NCBI Full Name:Muellerian-inhibiting factor
NCBI Synonym Full Names:anti-Mullerian hormone
NCBI Official Symbol:AMH  
NCBI Official Synonym Symbols:MIF; MIS  
NCBI Protein Information:muellerian-inhibiting factor
UniProt Protein Name:Muellerian-inhibiting factor
UniProt Synonym Protein Names:Anti-Muellerian hormone; AMH; Muellerian-inhibiting substance; MIS
Protein Family:Muellerian-inhibiting factor
UniProt Gene Name:AMH  
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