Human Alpha-Synuclein/SNCA Recombinant Protein (RPES4685)

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SKU:
RPES4685
Product type:
Recombinant Protein
Host species:
E.coli
Reactivity:
Human
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Description

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Human Alpha-Synuclein/SNCA Recombinant Protein

Alpha-Synuclein (SNCA) is a member of the Synuclein family. SNCA is expressed principally in brain but also expressed in low concentrations in all tissues except liver. SNCA interacts with UCHL1; Phospholipase D and histones. SNCA can include beta- and gamma-synuclein. In addition; SNCA is an important regulatory component of vesicular transport in neuronal cells. It has been suggested that SNCA is related to the pathogenesis of Parkinson's Disease and neurodegenerative disorders. Defects in SNCA will lead to Dementia Lewy Body (DLB).

Product Name:Human Alpha-Synuclein/SNCA Recombinant Protein (RPES4685)
Product Code:RPES4685
Size:10µg
Species:Human
Expressed Host:E.coli
Synonyms:Alpha-Synuclein, Non-A Beta Component of AD Amyloid, Non-A4 Component of Amyloid Precursor, NACP, SNCA, NACP, PARK1
Accession:P37840
Sequence:Met1-Ala140
Activity:Recombinant Human alpha -Synuclein is ideal for use as a control substrate for in vitro Ubiquitin conjugation using select Ubiquitin E3 ligases such as CHIP/Stub1. Aggregation T1/2 time of 70 µM human alpha -Synuclein protein is 1.07h(0.5 mM SDS).
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human SLAMF6 is produced by our E.coli expression system and the target gene encoding Met1-Ala140 is expressed.
Purity:> 95% as determined by reducing SDS-PAGE.
Mol Mass:14.46 kDa
AP Mol Mass:17 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of PBS;PH7.4.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

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