Human AK4 Recombinant Protein (RPPB2433)
- SKU:
- RPPB2433
- Product type:
- Recombinant Protein
- Size:
- 20ug
- Species:
- Human
- Target:
- AK4
- Synonyms:
- Adenylate Kinase 4
- AK3
- Adenylate Kinase 3-like 1
- AK3L1
- Source:
- Escherichia Coli
- Uniprot:
- P27144
Description
| Product Name: | Human AK4 Recombinant Protein |
| Product Code: | RPPB2433 |
| Size: | 20µg |
| Species: | Human |
| Target: | AK4 |
| Synonyms: | Adenylate Kinase 4, AK3, Adenylate Kinase 3-like 1, AK3L1, ATP-AMP transphosphorylase, Adenylate Kinase 3, GTP:AMP phosphotransferase, mitochondrial adenylate kinase-3, AK3L2, MGC166959, EC 2.7.4.3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | AK4 Human solution (1mg/1ml) containing 20mM Tris-HCl pH-8, 2mM DTT, 0.1M NaCl, and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MASKLLRAVI LGPPGSGKGT VCQRIAQNFG LQHLSSGHFL RENIKASTEV GEMAKQYIEK SLLVPDHVIT RLMMSELENR RGQHWLLDGF PRTLGQAEAL DKICEVDLVI SLNIPFETLK DRLSRRWIHP PSGRVYNLDF NPPHVHGIDD VTGEPLVQQE DDKPEAVAAR LRQYKDVAKP VIELYKSRGV LHQFSGTETN KIWPYVYTLF SNKITPIQSK EAY |
AK4 belongs to the adenylate kinase family of enzymes. AK4 protein is restricted to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide structures in a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Hereditary mutations which cause AK4 deficiencies in erythrocytes have been associated to hemolytic anemia.
AK4 Human Recombinant produced in E.Coli is a single, non-glycosylated,polypeptide chain containing 243 amino acids (1-223a.a.) and having a molecular mass of 27.4kDa. AK4 protein is fused to a 20 amino acid His tag at N-terminus and is purified by standard chromatography.
| UniProt Protein Function: | AK3L1: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. May also be active with GTP. Belongs to the adenylate kinase family. |
| UniProt Protein Details: | Protein type:Nucleotide Metabolism - purine; EC 2.7.4.10; EC 2.7.4.6; Mitochondrial; Kinase, other Chromosomal Location of Human Ortholog: 1p31.3 Cellular Component: mitochondrion; mitochondrial matrix Molecular Function:GTP binding; nucleoside diphosphate kinase activity; adenylate kinase activity; nucleoside triphosphate adenylate kinase activity; ATP binding Biological Process: response to drug; ATP metabolic process; nucleoside triphosphate biosynthetic process; nucleoside diphosphate phosphorylation; ADP biosynthetic process; brain development; liver development; AMP metabolic process; GTP metabolic process |
| NCBI Summary: | This gene encodes a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P27144 |
| NCBI GenInfo Identifier: | 125157 |
| NCBI Gene ID: | 205 |
| NCBI Accession: | P27144.1 |
| UniProt Related Accession: | P27144 |
| Molecular Weight: | ~ 25kDa |
| NCBI Full Name: | Adenylate kinase 4, mitochondrial |
| NCBI Synonym Full Names: | adenylate kinase 4 |
| NCBI Official Symbol: | AK4 |
| NCBI Official Synonym Symbols: | AK3; AK 4; AK3L1; AK3L2 |
| NCBI Protein Information: | adenylate kinase 4, mitochondrial |
| UniProt Protein Name: | Adenylate kinase 4, mitochondrial |
| UniProt Synonym Protein Names: | Adenylate kinase 3-like; GTP:AMP phosphotransferase AK4 |
| UniProt Gene Name: | AK4 |
| UniProt Entry Name: | KAD4_HUMAN |
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