Human AHSP Recombinant Protein (RPPB2721)

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SKU:
RPPB2721
Product type:
Recombinant Protein
Size:
50ug
Species:
Human
Target:
AHSP
Synonyms:
Alpha-hemoglobin-stabilizing protein
Synonyms:
Erythroid-associated factor
Synonyms:
Erythroid differentiation-related factor
Synonyms:
AHSP
Source:
Escherichia Coli
Uniprot:
Q9NZD4
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Description

Product Name:Human AHSP Recombinant Protein
Product Code:RPPB2721
Size:50µg
Species:Human
Target:AHSP
Synonyms:Alpha-hemoglobin-stabilizing protein, Erythroid-associated factor, Erythroid differentiation-related factor, AHSP, EDRF, ERAF.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The AHSP protein solution (1mg/ml) contains 20mM Tris-HCl buffer (pH8.0) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MALLKANKDL ISAGLKEFSV LLNQQVFNDP LVSEEDMVTV VEDWMNFYIN YYRQQVTGEP QERDKALQEL RQELNTLANP FLAKYRDFLK SHELPSHPPP SS

Alpha-hemoglobin stabilizing protein (AHSP) is an erythroid-specific protein that acts as a chaperone to prevent the aggregation of A-hemoglobin during normal erythroid cell development. AHSP specifically protects free A-hemoglobin from precipitation in live cells and in solution. AHSP is expected to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia. Furthermore, AHSP promotes alpha globin chain stability in human erythropoiesis. In addition, the AHSP stabilizes the alpha-Hb chain, thus avoiding its precipitation and its ability to generate ROS, which is implicated in cell death. AHSP is expressed in blood and bone marrow. AHSP subunit is a monomer, it forms a heterodimer with free alpha-hemoglobin. On the other hand, AHSP does not bind beta-hemoglobin nor alpha2beta2 hemoglobin A. AHSP is downregulated in TSEs (transmissible spongiform encephalopathies).

AHSP Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 102 amino acids (1-102 a.a.) and having a molecular mass of 11.8kDa.The AHSP is purified by proprietary chromatographic techniques.

UniProt Protein Function:AHSP: Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia. Belongs to the AHSP family.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: hemoglobin complex

Molecular Function:hemoglobin binding; unfolded protein binding

Biological Process: protein folding; protein stabilization; hemoglobin metabolic process; hemopoiesis

UniProt Code:Q9NZD4
NCBI GenInfo Identifier:23813669
NCBI Gene ID:51327
NCBI Accession:Q9NZD4.1
UniProt Secondary Accession:Q9NZD4,Q8TD01,
UniProt Related Accession:Q9NZD4
Molecular Weight:102
NCBI Full Name:Alpha-hemoglobin-stabilizing protein
NCBI Synonym Full Names:alpha hemoglobin stabilizing protein
NCBI Official Symbol:AHSP  
NCBI Official Synonym Symbols:EDRF; ERAF  
NCBI Protein Information:alpha-hemoglobin-stabilizing protein; erythroid associated factor; erythroid-associated factor; alpha hemoglobin stabilising protein; erythroid differentiation-related factor; erythroid differentiation associated factor
UniProt Protein Name:Alpha-hemoglobin-stabilizing protein
UniProt Synonym Protein Names:Erythroid differentiation-related factor; Erythroid-associated factor
Protein Family:Alpha-hemoglobin-stabilizing protein
UniProt Gene Name:AHSP  
UniProt Entry Name:AHSP_HUMAN
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