Human AHA1 Recombinant Protein (RPPB5192)

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SKU:
RPPB5192
Product type:
Recombinant Protein
Size:
50ug
Species:
Human
Target:
AHA1
Synonyms:
AHSA1
Synonyms:
ACA1
Synonyms:
p38
Synonyms:
C14orf3
Source:
Escherichia Coli
Uniprot:
O95433
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Description

Product Name:Human AHA1 Recombinant Protein
Product Code:RPPB5192
Size:50µg
Species:Human
Target:AHA1
Synonyms:AHSA1, ACA1, p38, C14orf3, Activator of HSP90 ATPase-1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The AHA1 protein solution contains 20mM Tris-HCI buffer (pH 8.0) and 2mM EDTA.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MATNVNNWHW TERDASNWST DKLKTLFLAV QVQNEEGKCE VTEVSKLDGE ASINNRKGKL IFFYEWSVKL NWTGTSKSGV QYKGHVEIPN LSDENSVDEV EISVSLAKDE PDTNLVALMKEEGVKLLREA MGIYISTLKT EFTQGMILPT MNGESVDPVG QPALKTEERK AKPAPSKTQARPVGVKIPTC KITLKETFLT SPEELYRVFT TQELVQAFTH APATLEADRG GKFHMVDGNV SGEFTDLVPE KHIVMKWRFK SWPEGHFATI TLTFIDKNGE TELCMEGRGI PAPEEERTRQ GWQRYYFEGI KQTFGYGARL

AHA1 is a cochaperone that stimulates hsp90 ATPase activity. AHSA1 binds the middle domain of Hsp90 (amino acid 272-627) and functions as an ATPase-activating protein that competes with p23 and other co-chaperones for Hsp90 binding.AHA1 affects a step in the endoplasmic reticulum to golgi trafficking.

AHA1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 320 amino acids (19-337) and having a molecular mass of 36.1 kDa.

UniProt Protein Function:AHSA1: Cochaperone that stimulates HSP90 ATPase activity. May affect a step in the endoplasmic reticulum to Golgi trafficking. Belongs to the AHA1 family.
UniProt Protein Details:

Protein type:Chaperone

Chromosomal Location of Human Ortholog: 14q24

Cellular Component: cytoplasm

Molecular Function:ATPase activator activity; chaperone binding; protein binding

UniProt Code:O95433
NCBI GenInfo Identifier:13124003
NCBI Gene ID:10598
NCBI Accession:O95433.1
UniProt Secondary Accession:O95433,Q96IL6, Q9P060, B2R9L2, B4DUR9,
UniProt Related Accession:O95433
Molecular Weight:32,340 Da
NCBI Full Name:Activator of 90 kDa heat shock protein ATPase homolog 1
NCBI Synonym Full Names:activator of Hsp90 ATPase activity 1
NCBI Official Symbol:AHSA1  
NCBI Official Synonym Symbols:p38; AHA1; hAha1; C14orf3  
NCBI Protein Information:activator of 90 kDa heat shock protein ATPase homolog 1
UniProt Protein Name:Activator of 90 kDa heat shock protein ATPase homolog 1
UniProt Synonym Protein Names:p38
Protein Family:Activator of 90 kDa heat shock protein ATPase
UniProt Gene Name:AHSA1  
UniProt Entry Name:AHSA1_HUMAN
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