Human AGR2 Recombinant Protein (RPPB2714)

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SKU:
RPPB2714
Product type:
Recombinant Protein
Size:
20ug
Species:
Human
Target:
AGR2
Synonyms:
Anterior gradient protein 2 homolog
Synonyms:
Secreted cement gland protein XAG-2 homolog
Synonyms:
AG-2
Synonyms:
hAG-2
Source:
Escherichia Coli
Uniprot:
O95994
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Description

Product Name:Human AGR2 Recombinant Protein
Product Code:RPPB2714
Size:20µg
Species:Human
Target:AGR2
Synonyms:Anterior gradient protein 2 homolog, Secreted cement gland protein XAG-2 homolog, AG-2, hAG-2, HPC8, AGR2, AG2, GOB-4, HAG-2, XAG-2.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:The protein contains 20mM Tris-HCl pH 8.0, 1mM DTT, 1mM EDTA and 10% Glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMRDT TVKPGAKKDT KDSRPKLPQT LSRGWGDQLI WTQTYEEALY KSKTSNKPLM IIHHLDECPH SQALKKVFAE NKEIQKLAEQ FVLLNLVYET TDKHLSPDGQ YVPRIMFVDP SLTVRADITG RYSNRLYAYE PADTALLLDN MKKALKLLKT EL

AGR2 (Anterior gradient 2 homolog) is the human orthologue of the secreted Xenopus laevis Anterior Gradient protein (XAG-2). This is a small, possibly secreted molecule of yet weakly defined functions that is widely expressed in human tissues. Expression of AGR2 shows a positive correlation with expression of estrogen receptor in breast carcinoma and a negative correlation with expression of EGF receptor.

AGR2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 191 amino acids (21-175 a.a.) and having a molecular mass of 21.9 kDa. AGR2 protein is fused to a 36 amino acid His-Tag at N-terminus and purified by standard chromatography.

UniProt Protein Function:AGR2: Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells. Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Interacts with LYPD3 and DAG1 (alphaDAG1). Interacts with MUC2; disulfide-linked. Expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. Expressed weakly in pituitary gland, salivary gland, mammary gland, bladder, appendix, ovary, fetal lung, uterus, pancreas, kidney, fetal kidney, testis, placenta, thyroid gland and in estrogen receptor (ER)-positive breast cancer cell lines. Belongs to the AGR family.
UniProt Protein Details:

Protein type:Secreted; Oncoprotein; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7p21.3

Cellular Component: endoplasmic reticulum; extracellular space

Molecular Function:epidermal growth factor receptor binding; protein binding; protein homodimerization activity

Biological Process: digestive tract morphogenesis; positive regulation of developmental growth; positive regulation of epidermal growth factor receptor signaling pathway

UniProt Code:O95994
NCBI GenInfo Identifier:67462105
NCBI Gene ID:10551
NCBI Accession:O95994.1
UniProt Related Accession:O95994
Molecular Weight:19,979 Da
NCBI Full Name:Anterior gradient protein 2 homolog
NCBI Synonym Full Names:anterior gradient 2, protein disulphide isomerase family member
NCBI Official Symbol:AGR2  
NCBI Official Synonym Symbols:AG2; GOB-4; HAG-2; XAG-2; PDIA17; HEL-S-116  
NCBI Protein Information:anterior gradient protein 2 homolog
UniProt Protein Name:Anterior gradient protein 2 homolog
UniProt Synonym Protein Names:HPC8; Secreted cement gland protein XAG-2 homolog
Protein Family:Anterior gradient protein
UniProt Gene Name:AGR2  
UniProt Entry Name:AGR2_HUMAN
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