Human Activin A Recombinant Protein (RPPB0004)

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SKU:
RPPB0004
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
Activin A
Synonyms:
Inhba
Synonyms:
Inhibin beta A
Synonyms:
FSH releasing protein
Source:
Nicotiana benthamiana plant
Uniprot:
P08476
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Description

Product Name:Human Activin A Recombinant Protein
Product Code:RPPB0004
Size:10µg
Species:Human
Target:Activin A
Synonyms:Inhba, Inhibin beta A, FSH releasing protein.
Source:Nicotiana benthamiana plant
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:Lyophilized from 1mg/ml solution in Tris HCl 0.05M buffer at pH 7.4.
Solubility:It is recommended to reconstitute the lyophilized Activin A in sterile 18M?-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized Activin A although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Activin A should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Purity:Greater than 97.0% as determined by Analysis by SDS-PAGE.
Amino Acid Sequence:HHHHHHGLEC DGKVNICCKK QFFVSFKDIG WNDWIIAPSG YHANYCEGEC PSHIAGTSGS SLSFHSTVIN HYRMRGHSPF ANLKSCCVPT KLRPMSMLYY DDGQNIIKKD IQNMIVEECG CS

Mature Activin A has two 116 amino acids residues betaA subunits (bA-bA). Activin displays an extensive variety of biological activities, including mesoderm induction, neural cell differentiation, bone remodelling, haematopoiesis, and reproductive physiology. Activins takes part in the production and regulation of hormones such as FSH, LH, GnRH and ACTH. Cells that are identified to express Activin A include fibroblasts, endothelial cells, hepatocytes, vascular smooth muscle cells, macrophages, keratinocytes, osteoclasts, bone marrow monocytes, prostatic epithelium, neurons, chondrocytes, osteoblasts, Leydig cells, Sertoli cells, and ovarian granulosa cells.

Activin A human Recombinant produced in Nicotiana benthamiana plant is a disulfide-linked homodimers of two betaA chains, each containing 116 amino residues (molecular formula C600H911N173O174S13) and 6-His-tag at the N-terminal having the total molecular mass of 27.4kDa.

UniProt Protein Function:INHBA: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Belongs to the TGF-beta family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7p14.1

Cellular Component: extracellular region

Molecular Function:cytokine activity; growth factor activity; hormone activity; identical protein binding; peptide hormone binding; protein binding; transforming growth factor beta receptor binding

Biological Process: activin receptor signaling pathway; cell cycle arrest; cell development; cell differentiation; cell surface receptor linked signal transduction; cell-cell signaling; defense response; G1/S transition of mitotic cell cycle; hair follicle development; hemoglobin biosynthetic process; hemopoietic progenitor cell differentiation; male gonad development; negative regulation of B cell differentiation; negative regulation of cell cycle; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of interferon-gamma biosynthetic process; negative regulation of macrophage differentiation; negative regulation of phosphorylation; odontogenesis; ovarian follicle development; palate development; positive regulation of cellular protein metabolic process; positive regulation of erythrocyte differentiation; positive regulation of follicle-stimulating hormone secretion; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; progesterone secretion; regulation of follicle-stimulating hormone secretion; regulation of MAPKKK cascade; regulation of transcription from RNA polymerase II promoter; response to drug; striatal medium spiny neuron differentiation

NCBI Summary:This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Elevated expression of this gene may be associated with cancer cachexia in human patients. [provided by RefSeq, Aug 2016]
UniProt Code:P08476
NCBI GenInfo Identifier:124279
NCBI Gene ID:3624
NCBI Accession:P08476.2
UniProt Secondary Accession:P08476,Q14599,
UniProt Related Accession:P08476
Molecular Weight:47,442 Da
NCBI Full Name:Inhibin beta A chain
NCBI Synonym Full Names:inhibin beta A subunit
NCBI Official Symbol:INHBA  
NCBI Official Synonym Symbols:EDF; FRP  
NCBI Protein Information:inhibin beta A chain
UniProt Protein Name:Inhibin beta A chain
UniProt Synonym Protein Names:Activin beta-A chain; Erythroid differentiation protein; EDF
Protein Family:Inhibin
UniProt Gene Name:INHBA  
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