Human ACOT13 Recombinant Protein (RPPB1334)

(No reviews yet) Write a Review

제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.

주문
SKU:
RPPB1334
Product type:
Recombinant Protein
Size:
10ug
Species:
Human
Target:
ACOT13
Synonyms:
Acyl-coenzyme A thioesterase 13
Synonyms:
Acyl-CoA thioesterase 13
Synonyms:
Thioesterase superfamily member 2
Synonyms:
ACOT13
Source:
Escherichia Coli
Uniprot:
Q9NPJ3
€0.00
Frequently bought together:

Description

Product Name:Human ACOT13 Recombinant Protein
Product Code:RPPB1334
Size:10µg
Species:Human
Target:ACOT13
Synonyms:Acyl-coenzyme A thioesterase 13, Acyl-CoA thioesterase 13, Thioesterase superfamily member 2, ACOT13, THEM2, HT012, MGC4961, PNAS-27, ACOT13.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The ACOT13 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MTSMTQSLRE VIKAMTKARN FERVLGKITL VSAAPGKVIC EMKVEEEHTN AIGTLHGGLT ATLVDNISTM ALLCTERGAP GVSVDMNITY MSPAKLGEDI VITAHVLKQG KTLAFTSVDL TNKATGKLIA QGRHTKHLGN

Acyl-coenzyme A thioesterase 13 (ACOT13) belongs to the thioesterase subfamily of esterase family. ACOT13 is highly expressed in the kidney with moderate expression in the brain, liver and intestines. ACOT13 contains a hotdog-fold and is thought to co-localize with microtubules, possibly having a role in cellular proliferation events. Deletion of a segment of the q arm of chromosome 6 is linked to early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus.

ACOT13 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 160 amino acids (1-140 a.a.) and having a molecular mass of 17.1kDa. The ACOT13 is purified by proprietary chromatographic techniques.

UniProt Protein Function:THEM2: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3- hydroxyphenylacetyl-CoA and 3,4-dihydrohyphenylacetyl-CoA (in vitro). Belongs to the thioesterase PaaI family.
UniProt Protein Details:

Protein type:EC 3.1.2.-

Chromosomal Location of Human Ortholog: 6p22.3

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function:acyl-CoA hydrolase activity

Biological Process: protein homotetramerization

NCBI Summary:This gene encodes a member of the thioesterase superfamily. In humans, the protein co-localizes with microtubules and is essential for sustained cell proliferation. The orthologous mouse protein forms a homotetramer and is associated with mitochondria. The mouse protein functions as a medium- and long-chain acyl-CoA thioesterase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2009]
UniProt Code:Q9NPJ3
NCBI GenInfo Identifier:23396822
NCBI Gene ID:55856
NCBI Accession:Q9NPJ3.1
UniProt Secondary Accession:Q9NPJ3,O95549, F5H2L4,
UniProt Related Accession:Q9NPJ3
Molecular Weight:12,366 Da
NCBI Full Name:Acyl-coenzyme A thioesterase 13
NCBI Synonym Full Names:acyl-CoA thioesterase 13
NCBI Official Symbol:ACOT13  
NCBI Official Synonym Symbols:HT012; THEM2; PNAS-27  
NCBI Protein Information:acyl-coenzyme A thioesterase 13
UniProt Protein Name:Acyl-coenzyme A thioesterase 13
UniProt Synonym Protein Names:Thioesterase superfamily member 2
UniProt Gene Name:ACOT13  
View AllClose

Related Products