HTLV-1 p24 core Recombinant Protein (RPPB5606)
- SKU:
- RPPB5606
- Product type:
- Recombinant Protein
- Size:
- 0.5mg
- Species:
- HTLV-1
- Target:
- p24 core
- Source:
- Escherichia Coli
Description
| Product Name: | HTLV-1 p24 core Recombinant Protein |
| Product Code: | RPPB5606 |
| Size: | 0.5mg |
| Species: | HTLV-1 |
| Target: | p24 core |
| Source: | Escherichia Coli |
| Formulation: | 50mM NaPO4 pH 6.0, containing 1mM DTT & 1mM EDTA. |
| Stability: | HTLV-1 p24 although stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles. |
| Purity: | HTLV-1 p24 protein is >95% pure as determined by 10% PAGE (coomassie staining) and RP-HPLC. |
Human T-lymphotropic virus (HTLV) is a human, single-stranded RNA retrovirus that causes T-cell leukemia and T-cell lymphoma. The virus activates a subset of T-helper cellscalled Th1cells. The result is a proliferation of Th1 cells and overproduction of Th1 related cytokines (mainly IFN-gamma and TNF-alpha). Feedback mechanisms of these cytokines cause a suppression of the Th2 lymphocytes and a reduction of Th2 cytokine production (mainly IL-4, IL-5, IL-10 and IL-13). The end result is a reduction in the ability of the infected host to mount an adequate immune response to invading organisms that require a predominantly Th2 dependant response (these include parasitic infections and production of mucosal and humoral antibodies).
The E.Coli derived recombinant protein contains the full-length sequence of HTLV-I p24, spanning all of p24.The protein contains 214 amino acids having an Mw of 24kDa.
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