HTLV-1 gp46 mosaic Recombinant Protein (RPPB5609)
- SKU:
- RPPB5609
- Product type:
- Recombinant Protein
- Size:
- 0.5mg
- Species:
- HTLV-1
- Target:
- gp46 mosaic
- Source:
- Escherichia Coli
Description
| Product Name: | HTLV-1 gp46 mosaic Recombinant Protein |
| Product Code: | RPPB5609 |
| Size: | 0.5mg |
| Species: | HTLV-1 |
| Target: | gp46 mosaic |
| Source: | Escherichia Coli |
| Formulation: | The protein solution contains 20mM Phosphate buffer pH 7.5. |
| Stability: | HTLV-1 gp46 although stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles. |
| Purity: | Protein is >90% pure as determined by SDS-PAGE. |
| Amino Acid Sequence: | PSCCTLTVGV SSYHSKPCNP AQPVCSWTLD LLALSADRAL QPPCPNLVSY SSYHATYSLY LFPHWIKKPN RNGGGYYSAS YSDPCSLKCP YLGCQSWTCP YTGAVSSPYW KFQQDVNFTQ EVSHLNINLH FSKCGFPFSL LVDAPGYDPI WFLNTEPSQL PPTAPPLLSH SNLDHILEPS IPWKSKLLTL VQLTLQSTNY TCIVCIDRAS LSTWHVLYSP NVSVPSPSST PLLYPSLALP APHLTLPFNW THCFDPQIQA IVSSPCHNSL ILPPFSLSPV PTLGSRSRRA |
Human T-lymphotropic virus (HTLV) is a human, single-stranded RNA retrovirus that causes T-cell leukemia and T-cell lymphoma. The virus activates a subset of T-helper cellscalled Th1cells. The result is a proliferation of Th1 cells and overproduction of Th1 related cytokines (mainly IFN-gamma and TNF-alpha). Feedback mechanisms of these cytokines cause a suppression of the Th2 lymphocytes and a reduction of Th2 cytokine production (mainly IL-4, IL-5, IL-10 and IL-13). The end result is a reduction in the ability of the infected host to mount an adequate immune response to invading organisms that require a predominantly Th2 dependant response (these include parasitic infections and production of mucosal and humoral antibodies).
The E.Coli derived recombinant mosaic protein contains the gp46 immunodominant region, 21-313 amino acids; Mw on SDA-PAGE is 34.2kDa and fuse to 6 histidines at C-terminus.
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