HSF4 Antibody (PACO09819)
- SKU:
- PACO09819
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | HSF4 Antibody (PACO09819) |
| Antibody SKU: | PACO09819 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Human HSF4 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | heat shock transcription factor 4;HSF4;CTM ; |
| UniProt Protein Function: | HSF4: DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription. Defects in HSF4 are the cause of cataract, zonular (CZ). A form of zonular cataract. Zonular or lamellar cataracts are opacities, broad or narrow, usually consisting of powdery white dots affecting only certain layers or zones between the cortex and nucleus of an otherwise clear lens. The opacity may be so dense as to render the entire central region of the lens completely opaque, or so translucent that vision is hardly if at all impeded. Zonular cataracts generally do not involve the embryonic nucleus, though sometimes they involve the fetal nucleus. Usually sharply separated from a clear cortex outside them, they may have projections from their outer edges known as riders or spokes. Defects in HSF4 are the cause of cataract Marner type (CAM). A form of cataract with variable and progressive opacities. Affected individuals present with zonular cataract, although some have nuclear, anterior polar, or stellate cataract. Finger malformation is observed in some kindreds. Belongs to the HSF family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor; Cell development/differentiation; DNA-binding Chromosomal Location of Human Ortholog: 16q21 Cellular Component: nucleoplasm Molecular Function:transcription corepressor activity Biological Process: regulation of transcription, DNA-dependent Disease: Cataract 5, Multiple Types |
| NCBI Summary: | Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9ULV5 |
| NCBI GenInfo Identifier: | 296434534 |
| NCBI Gene ID: | 3299 |
| NCBI Accession: | Q9ULV5.2 |
| UniProt Secondary Accession: | Q9ULV5,Q99472, Q9ULV6, |
| UniProt Related Accession: | Q9ULV5 |
| Molecular Weight: | 49,952 Da |
| NCBI Full Name: | Heat shock factor protein 4 |
| NCBI Synonym Full Names: | heat shock transcription factor 4 |
| NCBI Official Symbol: | HSF4 |
| NCBI Official Synonym Symbols: | CTM; CTRCT5 |
| NCBI Protein Information: | heat shock factor protein 4 |
| UniProt Protein Name: | Heat shock factor protein 4 |
| UniProt Synonym Protein Names: | Heat shock transcription factor 4; HSTF 4 |
| Protein Family: | Heat shock factor protein |
| UniProt Gene Name: | HSF4 |
| UniProt Entry Name: | HSF4_HUMAN |
Related Products
Human HSF4 ELISA Kit
Human Heat shock factor protein 4 (HSF4) ELISA Kit
