HORMAD1 Antibody (PACO13690)
- SKU:
- PACO13690
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | HORMAD1 Antibody (PACO13690) |
Antibody SKU: | PACO13690 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Human HORMAD1 |
Form: | Liquid |
Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Synonyms: | HORMA domain containing 1;HORMAD1;CT46;DKFZp434A1315;NOHMA;RP11-363I22.1 ; |
UniProt Protein Function: | HORMAD1: Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cancer Testis Antigen (CTA) Chromosomal Location of Human Ortholog: 1q21.3 Cellular Component: chromosome; nucleus Biological Process: blastocyst development; meiosis; meiotic DNA double-strand break formation; meiotic recombination checkpoint; meiotic sister chromatid cohesion; oogenesis; spermatogenesis; synaptonemal complex assembly |
NCBI Summary: | This gene encodes a HORMA domain-containing protein. HORMA domains are involved in chromatin binding and play a role in cell cycle regulation. The encoded protein may play a role in meiosis, and expression of this gene is a potential marker for cancer. A pseudogene of this gene is located on the long arm of chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010] |
UniProt Code: | Q86X24 |
NCBI GenInfo Identifier: | 74750516 |
NCBI Gene ID: | 84072 |
NCBI Accession: | Q86X24.1 |
UniProt Secondary Accession: | Q86X24,Q4G114, Q5T5I3, Q5T5I4, Q5T5I5, Q6FIC1, Q9H0K8 A6NMK2, B3KUK1, |
UniProt Related Accession: | Q86X24 |
Molecular Weight: | 36,676 Da |
NCBI Full Name: | HORMA domain-containing protein 1 |
NCBI Synonym Full Names: | HORMA domain containing 1 |
NCBI Official Symbol: | HORMAD1 |
NCBI Official Synonym Symbols: | CT46; NOHMA |
NCBI Protein Information: | HORMA domain-containing protein 1 |
UniProt Protein Name: | HORMA domain-containing protein 1 |
UniProt Synonym Protein Names: | Cancer/testis antigen 46; CT46; Newborn ovary HORMA protein |
Protein Family: | HORMA domain-containing protein |
UniProt Gene Name: | HORMAD1 |
UniProt Entry Name: | HORM1_HUMAN |