HLA-DOA Antibody (PACO22370)
- SKU:
- PACO22370
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | HLA-DOA Antibody (PACO22370) |
| Antibody SKU: | PACO22370 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from internal of human HLA-DOA. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from COLO cells, using HLA-DOA antibody. |
| Background: | Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM. |
| Synonyms: | HLA class II histocompatibility antigen; DO alpha chain [Precursor]; MHC class II antigen DOA; MHC DZ alpha; MHC DN-alpha |
| UniProt Protein Function: | HLA-DOA: Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM. Belongs to the MHC class II family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: endosome membrane; integral to membrane; lysosomal membrane; MHC class II protein complex; plasma membrane Molecular Function:MHC class II receptor activity; protein binding Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; immune response; negative regulation of antigen processing and presentation of peptide antigen via MHC class II; regulation of T cell differentiation; signal transduction |
| NCBI Summary: | HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P06340 |
| NCBI GenInfo Identifier: | 122210 |
| NCBI Gene ID: | 3111 |
| NCBI Accession: | P06340.1 |
| UniProt Secondary Accession: | P06340,Q58HU0, Q58HU1, Q5STC7, Q9TQC6, Q9TQC7, Q9TQC8 Q9TQC9, Q9TQD0, Q9TQD1, Q9TQD2, Q9TQD3, |
| UniProt Related Accession: | P06340 |
| Molecular Weight: | 27,599 Da |
| NCBI Full Name: | HLA class II histocompatibility antigen, DO alpha chain |
| NCBI Synonym Full Names: | major histocompatibility complex, class II, DO alpha |
| NCBI Official Symbol: | HLA-DOA |
| NCBI Official Synonym Symbols: | HLADZ; HLA-DNA; HLA-DZA |
| NCBI Protein Information: | HLA class II histocompatibility antigen, DO alpha chain |
| UniProt Protein Name: | HLA class II histocompatibility antigen, DO alpha chain |
| UniProt Synonym Protein Names: | MHC DN-alpha; MHC DZ alpha; MHC class II antigen DOA |
| Protein Family: | HLA class II histocompatibility antigen |
| UniProt Gene Name: | HLA-DOA |
| UniProt Entry Name: | DOA_HUMAN |
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