HCN1 Antibody (PACO58785)
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주문- SKU:
- PACO58785
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | HCN1 Antibody (PACO58785) |
Antibody SKU: | PACO58785 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:500-1:1000, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 protein (784-887AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | IHC image of PACO58785 diluted at 1:500 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
![]() | Immunofluorescence staining of HepG2 cells with PACO58785 at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
![]() | IHC image of PACO58785 diluted at 1:500 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
Background: | Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli. |
Synonyms: | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Brain cyclic nucleotide-gated channel 1) (BCNG-1), HCN1, BCNG1 |
UniProt Protein Function: | HCN1: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. May mediate responses to sour stimuli. Belongs to the potassium channel HCN family. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 5p12 Cellular Component: axon; integral to plasma membrane; dendrite; integral to membrane; plasma membrane Molecular Function:identical protein binding; voltage-gated potassium channel activity; intracellular cAMP activated cation channel activity; potassium channel activity; voltage-gated sodium channel activity; cAMP binding Biological Process: synaptic transmission; regulation of membrane potential; apical protein localization; retinal cone cell development; potassium ion transport Disease: Epileptic Encephalopathy, Early Infantile, 24 |
NCBI Summary: | The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. [provided by RefSeq, Oct 2011] |
UniProt Code: | O60741 |
NCBI GenInfo Identifier: | 229462966 |
NCBI Gene ID: | 348980 |
NCBI Accession: | O60741.3 |
UniProt Related Accession: | O60741 |
Molecular Weight: | 890 |
NCBI Full Name: | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 |
NCBI Synonym Full Names: | hyperpolarization activated cyclic nucleotide-gated potassium channel 1 |
NCBI Official Symbol: | HCN1 |
NCBI Official Synonym Symbols: | BCNG1; HAC-2; BCNG-1; EIEE24 |
NCBI Protein Information: | potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1; brain cyclic nucleotide gated channel 1; brain cyclic nucleotide-gated channel 1 |
UniProt Protein Name: | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 |
UniProt Synonym Protein Names: | Brain cyclic nucleotide-gated channel 1; BCNG-1 |
Protein Family: | Anaphase-promoting complex |
UniProt Gene Name: | HCN1 |
UniProt Entry Name: | HCN1_HUMAN |