Gzma Antibody (PACO27281)
- SKU:
- PACO27281
- Product type:
- Antibody
- Reactivity:
- Mouse
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | Gzma Antibody (PACO27281) |
| Antibody SKU: | PACO27281 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
| Species Reactivity: | Mouse, Human |
| Immunogen: | Recombinant Mouse Granzyme A protein (29-260AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot Positive WB detected in: Raji whole cell lysate, Jurkat whole cell lysate, K562 whole cell lysate All lanes: Gzma antibody at 3µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 29 kDa Observed band size: 29 kDa . |
| Background: | Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA (By similarity). |
| Synonyms: | Granzyme A (EC 3.4.21.78) (Autocrine thymic lymphoma granzyme-like serine protease) (CTLA-3) (Fragmentin-1) (T cell-specific serine protease 1) (TSP-1), Gzma, Ctla-3 Ctla3 Mtsp-1 |
| UniProt Protein Function: | GZMA: This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Involved in apoptosis. Homodimer; disulfide-linked. Interacts with APEX1. Dexamethasone (DEX) induces expression of isoform beta and represses expression of isoform alpha. The alteration in expression is mediated by binding of glucocorticoid receptor to independent promoters adjacent to the alternative first exons of isoform alpha and isoform beta. Belongs to the peptidase S1 family. Granzyme subfamily. 2 isoforms of the human protein are produced by alternative promoter. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Protease; Secreted; EC 3.4.21.78; Apoptosis Cellular Component: extracellular region; nucleus Molecular Function:peptidase activity; protein homodimerization activity; hydrolase activity; serine-type peptidase activity; serine-type endopeptidase activity; catalytic activity Biological Process: proteolysis involved in cellular protein catabolic process; positive regulation of apoptosis; apoptosis; cytolysis; negative regulation of oxidoreductase activity; negative regulation of endodeoxyribonuclease activity; proteolysis; negative regulation of DNA binding |
| UniProt Code: | P11032 |
| NCBI GenInfo Identifier: | 6754102 |
| NCBI Gene ID: | 14938 |
| NCBI Accession: | NP_034500.1 |
| UniProt Secondary Accession: | P11032,P15118, |
| UniProt Related Accession: | P11032 |
| Molecular Weight: | 39.6 kDa |
| NCBI Full Name: | granzyme A |
| NCBI Synonym Full Names: | granzyme A |
| NCBI Official Symbol: | Gzma |
| NCBI Official Synonym Symbols: | Hf; SE1; TSP1; Ctla3; TSP-1; Ctla-3; AW494114 |
| NCBI Protein Information: | granzyme A; H factor; BLT esterase; fragmentin-1; Hanukah factor; serine esterase 1; t cell-specific serine protease 1; autocrine thymic lymphoma granzyme-like serine protease |
| UniProt Protein Name: | Granzyme A |
| UniProt Synonym Protein Names: | Autocrine thymic lymphoma granzyme-like serine protease; CTLA-3; Fragmentin-1; T cell-specific serine protease 1; TSP-1 |
| Protein Family: | Granzyme |
| UniProt Gene Name: | Gzma |
| UniProt Entry Name: | GRAA_MOUSE |
| ELISA Kits |
| Mouse Granzyme A (Gzma) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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