GNL3L Antibody (PACO40662)
- SKU:
- PACO40662
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | GNL3L Antibody (PACO40662) |
| Antibody SKU: | PACO40662 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Guanine nucleotide-binding protein-like 3-like protein (1-582AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP. |
| Synonyms: | Guanine nucleotide-binding protein-like 3-like protein, GNL3L |
| UniProt Protein Function: | GNL3L: Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP. Belongs to the MMR1/HSR1 GTP-binding protein family.Protein type: NucleolusChromosomal Location of Human Ortholog: Xp11.22Cellular Component: cytoplasm; membrane; mitochondrion; nucleolus; nucleus; telomerase holoenzyme complexMolecular Function: GTPase activity; protein bindingBiological Process: negative regulation of protein binding; negative regulation of protein sumoylation; negative regulation of protein ubiquitination; negative regulation of telomere maintenance via telomerase; regulation of protein stability; ribosome biogenesis and assembly |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010] |
| UniProt Code: | Q9NVN8 |
| NCBI GenInfo Identifier: | 74752999 |
| NCBI Gene ID: | 54552 |
| NCBI Accession: | Q9NVN8.1 |
| UniProt Secondary Accession: | Q9NVN8 |
| UniProt Related Accession: | Q9NVN8 |
| Molecular Weight: | 65,573 Da |
| NCBI Full Name: | Guanine nucleotide-binding protein-like 3-like protein |
| NCBI Synonym Full Names: | G protein nucleolar 3 like |
| NCBI Official Symbol: | GNL3L |
| NCBI Official Synonym Symbols: | GNL3B |
| NCBI Protein Information: | guanine nucleotide-binding protein-like 3-like protein |
| UniProt Protein Name: | Guanine nucleotide-binding protein-like 3-like protein |
| UniProt Synonym Protein Names: | |
| Protein Family: | Guanine nucleotide-binding protein-like 3-like protein |
| UniProt Gene Name: | GNL3L |
| UniProt Entry Name: | GNL3L_HUMAN |
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