GIT1 Antibody (PACO06511)
- SKU:
- PACO06511
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | GIT1 Antibody (PACO06511) |
| Antibody SKU: | PACO06511 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:20000, WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from the C-terminal region of human GIT1. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot analysis of NIH-3T3 A549 cells using GIT1 Polyclonal Antibody. |
 | Western Blot analysis of HepG2 cells using GIT1 Polyclonal Antibody. |
| Synonyms: | GIT1; ARF GTPase-activating protein GIT1; ARF GAP GIT1; Cool-associated and tyrosine-phosphorylated protein 1; CAT-1; CAT1; G protein-coupled receptor kinase-interactor 1; GRK-interacting protein 1 |
| UniProt Protein Function: | GIT1: a multidomain, adaptor protein that regulates cellular processes, such as migration and protrusive activity, by bringing together various signaling molecules, including PIX, PAK, and paxillin. Phosphorylation on Ser-709 increases its binding to paxillin and regulates cellular protrusions. Possesses ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. Functions as part of a multi-molecular signaling complex that regulates membrane protrusions and cell migration. Regulates PLC-gamma activation by c-Src and integrates signal transduction by G protein coupled receptors (GPCR)s and tyrosine kinase receptors (TKRs). |
| UniProt Protein Details: | Protein type:GAPs, ARF; Motility/polarity/chemotaxis; GAPs Chromosomal Location of Human Ortholog: 17p11.2 Cellular Component: cytoplasm; cytosol; focal adhesion; membrane Molecular Function:protein binding Biological Process: ephrin receptor signaling pathway; regulation of cytokinesis; regulation of G-protein coupled receptor protein signaling pathway |
| UniProt Code: | Q9Y2X7 |
| NCBI GenInfo Identifier: | 45645212 |
| NCBI Gene ID: | 28964 |
| NCBI Accession: | Q9Y2X7.2 |
| UniProt Secondary Accession: | Q9Y2X7,Q86SS0, Q9BRJ4, B4DGU9, B4DSV3, |
| UniProt Related Accession: | Q9Y2X7 |
| Molecular Weight: | 85,446 Da |
| NCBI Full Name: | ARF GTPase-activating protein GIT1 |
| NCBI Synonym Full Names: | GIT ArfGAP 1 |
| NCBI Official Symbol: | GIT1 |
| NCBI Protein Information: | ARF GTPase-activating protein GIT1 |
| UniProt Protein Name: | ARF GTPase-activating protein GIT1 |
| UniProt Synonym Protein Names: | Cool-associated and tyrosine-phosphorylated protein 1; CAT-1; CAT1; G protein-coupled receptor kinase-interactor 1; GRK-interacting protein 1 |
| Protein Family: | ARF GTPase-activating protein |
| UniProt Gene Name: | GIT1 |
| UniProt Entry Name: | GIT1_HUMAN |
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