GCHFR Antibody (PACO45858)
- SKU:
- PACO45858
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | GCHFR Antibody (PACO45858) |
| Antibody SKU: | PACO45858 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human GTP cyclohydrolase 1 feedback regulatory protein (11-55AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO45858 at dilution of 1:100. |
 | Immunofluorescent analysis of Hela cells using PACO45858 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine. |
| Synonyms: | GTP cyclohydrolase 1 feedback regulatory protein (GFRP) (GTP cyclohydrolase I feedback regulatory protein) (p35), GCHFR, GFRP |
| UniProt Protein Function: | GCHFR: Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine. Belongs to the GFRP family.Protein type: InhibitorChromosomal Location of Human Ortholog: 15q15Cellular Component: cytoplasm; cytosol; dendrite; melanosome; nuclear membrane; nucleusMolecular Function: protein bindingBiological Process: neurotransmitter metabolic process; nitric oxide biosynthetic process; regulation of nitric-oxide synthase activity |
| UniProt Protein Details: | |
| NCBI Summary: | GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P30047 |
| NCBI GenInfo Identifier: | 2506906 |
| NCBI Gene ID: | 2644 |
| NCBI Accession: | P30047.3 |
| UniProt Secondary Accession: | P30047,Q2M1Q2, Q99749, B2R4L6, B7ZLM8 |
| UniProt Related Accession: | P30047 |
| Molecular Weight: | 8,555 Da |
| NCBI Full Name: | GTP cyclohydrolase 1 feedback regulatory protein |
| NCBI Synonym Full Names: | GTP cyclohydrolase I feedback regulator |
| NCBI Official Symbol: | GCHFR |
| NCBI Official Synonym Symbols: | P35; GFRP; HsT16933 |
| NCBI Protein Information: | GTP cyclohydrolase 1 feedback regulatory protein |
| UniProt Protein Name: | GTP cyclohydrolase 1 feedback regulatory protein |
| UniProt Synonym Protein Names: | GTP cyclohydrolase I feedback regulatory protein; p35 |
| Protein Family: | GTP cyclohydrolase 1 feedback regulatory protein |
| UniProt Gene Name: | GCHFR |
| UniProt Entry Name: | GFRP_HUMAN |
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