GATA6 Transcription Factor Activity Assay
- SKU:
- TFAB00117
- Product Type:
- ELISA Kit
- ELISA Type:
- Transcription Factor Assay
- Analytes:
- GATA6
- Reactivity:
- Human
- Mouse
- Rat
Description
GATA6 Transcription Factor Activity Assay
The GATA6 Transcription Factor Activity Assay Kit is specifically designed to measure the activity of the GATA6 transcription factor in various biological samples. With high sensitivity and precision, this assay kit provides accurate and reliable results, making it a valuable tool for researchers studying the role of GATA6 in gene regulation and cellular processes.GATA6 is a key transcription factor involved in the regulation of genes related to cell differentiation, development, and disease. Its dysregulation has been implicated in various disorders, including cardiovascular diseases, gastrointestinal cancers, and diabetes.
By accurately measuring GATA6 activity, researchers can gain insights into the molecular mechanisms underlying these conditions and potentially identify novel therapeutic targets.This kit includes all the necessary components for convenient and efficient measurement of GATA6 transcription factor activity, allowing researchers to streamline their experiments and obtain valuable data with ease. With its versatility and reliability, the GATA6 Transcription Factor Activity Assay Kit is an essential tool for advancing research in the field of gene regulation and cellular biology.
| Product Name: | GATA6 Transcription Factor Activity Assay |
| Product Code: | TFAB00117 |
| Target: | GATA6 |
| Synonyms: | GATA-binding factor 6 |
| Reactivity: | Human, Mouse, Rat |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie GATA6 transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | GATA6: Transcriptional activator that regulates SEMA3C and PLXNA2. Thought to be important for regulating terminal differentiation and/or proliferation. Interacts with LMCD1. Expressed in heart, gut and gut-derived tissues. 2 isoforms of the human protein are produced by alternative initiation. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Transcription factor Chromosomal Location of Human Ortholog: 18q11.1-q11.2 Cellular Component: nucleoplasm; nucleus; transcription factor complex Molecular Function:chromatin binding; protein binding; protein kinase binding; transcription factor activity; transcription factor binding Biological Process: blood coagulation; cell development; cell fate commitment; cellular protein metabolic process; male gonad development; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of transforming growth factor-beta1 production; negative regulation of transforming growth factor-beta2 production; positive regulation of angiogenesis; positive regulation of BMP signaling pathway; response to drug; smooth muscle cell differentiation; transcription from RNA polymerase II promoter Disease: Atrial Septal Defect 9; Atrioventricular Septal Defect 5; Conotruncal Heart Malformations; Heart Defects, Congenital, And Other Congenital Anomalies; Tetralogy Of Fallot |
| NCBI Summary: | This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects. [provided by RefSeq, Mar 2012] |
| UniProt Code: | Q92908 |
| NCBI GenInfo Identifier: | 215273987 |
| NCBI Gene ID: | 2627 |
| NCBI Accession: | Q92908.2 |
| UniProt Secondary Accession: | Q92908,P78327, B0YJ17, |
| UniProt Related Accession: | Q92908 |
| Molecular Weight: | 45,386 Da |
| NCBI Full Name: | Transcription factor GATA-6 |
| NCBI Synonym Full Names: | GATA binding protein 6 |
| NCBI Official Symbol: | GATA6 |
| NCBI Protein Information: | transcription factor GATA-6 |
| UniProt Protein Name: | Transcription factor GATA-6 |
| UniProt Synonym Protein Names: | GATA-binding factor 6 |
| Protein Family: | GATA transcription factor |
| UniProt Gene Name: | GATA6 |
| UniProt Entry Name: | GATA6_HUMAN |
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