GATA1 (Phospho-Ser142) Transcription Factor Activity Assay
- SKU:
- TFAB00029
- Product Type:
- ELISA Kit
- ELISA Type:
- Transcription Factor Assay
- Analytes:
- GATA1 (Phospho-Ser142)
- Reactivity:
- Human
Description
GATA1 (Phospho-Ser142)Transcription Factor Activity Assay
The GATA1 Phospho-Ser142 Transcription Factor Activity Assay is a powerful tool for researchers studying gene regulation and transcription. This assay kit allows for the precise measurement of GATA1 activity by detecting phosphorylation at serine 142, providing valuable insights into the regulatory mechanisms of this important transcription factor.GATA1 is known for its role in hematopoiesis, playing a critical role in the development and differentiation of red blood cells. Phosphorylation of GATA1 at serine 142 has been linked to changes in its transcriptional activity, making it a key target for studies on blood disorders and hematological malignancies.
With its high sensitivity and specificity, the GATA1 Phospho-Ser142 Transcription Factor Activity Assay ensures accurate and reliable results, paving the way for advancements in research on gene expression and disease mechanisms. This kit is essential for researchers looking to deepen their understanding of transcriptional regulation and its implications for human health.
| Product Name: | GATA1 (Phospho-Ser142) Transcription Factor Activity Assay |
| Product Code: | TFAB00029 |
| Target: | GATA1 (Phospho-Ser142) |
| Synonyms: | Eryf1, GATA-binding factor 1, GATA-1, GF-1, NF-E1 transcription factor activity protein |
| Reactivity: | Human |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie GATA1 (Phospho-Ser142) transcription factor activity assay allows for the detection and qualitative analysis of GATA1 (Phospho-Ser142) active transcription factors in eukaryotic nuclear or cell lysates.
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (PubMed:24245781). |
| NCBI Summary: | This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P15976 |
| NCBI GenInfo Identifier: | 120956 |
| NCBI Gene ID: | 2623 |
| NCBI Accession: | P15976.1 |
| UniProt Secondary Accession: | P15976,Q96GB8, |
| UniProt Related Accession: | P15976 |
| Molecular Weight: | 34,232 Da |
| NCBI Full Name: | Erythroid transcription factor |
| NCBI Synonym Full Names: | GATA binding protein 1 |
| NCBI Official Symbol: | GATA1 |
| NCBI Official Synonym Symbols: | GF1; GF-1; NFE1; XLTT; ERYF1; NF-E1; XLANP; XLTDA; GATA-1 |
| NCBI Protein Information: | erythroid transcription factor |
| UniProt Protein Name: | Erythroid transcription factor |
| UniProt Synonym Protein Names: | Eryf1; GATA-binding factor 1; GATA-1; GF-1; NF-E1 DNA-binding protein |
| Protein Family: | GATA transcription factor |
| UniProt Gene Name: | GATA1 |
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