GAB1 Antibody (PACO54110)
- SKU:
- PACO54110
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | GAB1 Antibody (PACO54110) |
| Antibody SKU: | PACO54110 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human GRB2-associated-binding protein 1 protein (119-329AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO54110 at dilution of 1:100. |
 | Immunofluorescence staining of HepG2 cells with PACO54110 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human breast cancer using PACO54110 at dilution of 1:100. |
| Background: | Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). |
| Synonyms: | GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1), GAB1 |
| UniProt Protein Function: | GAB1: Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2. Interacts with PTPRJ. Identified in a complex containing FRS2, GRB2, GAB1, PIK3R1 and SOS1. Interacts (phosphorylated) with PTPN11. Interacts with HCK. Belongs to the GAB family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 4q31.21 Cellular Component: cytosol Molecular Function:protein binding; SH3/SH2 adaptor activity; signal transducer activity Biological Process: activation of JNK activity; cell proliferation; epidermal growth factor receptor signaling pathway; epidermis development; fibroblast growth factor receptor signaling pathway; heart development; innate immune response; insulin receptor signaling pathway; nerve growth factor receptor signaling pathway; phosphoinositide-mediated signaling; platelet-derived growth factor receptor signaling pathway; regulation of cell migration; response to oxidative stress |
| NCBI Summary: | The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] |
| UniProt Code: | Q13480 |
| NCBI GenInfo Identifier: | 90180201 |
| NCBI Gene ID: | 2549 |
| NCBI Accession: | Q13480.2 |
| UniProt Secondary Accession: | Q13480,Q4W5G2, Q6P1W2, A8K152, |
| UniProt Related Accession: | Q13480 |
| Molecular Weight: | 80,005 Da |
| NCBI Full Name: | GRB2-associated-binding protein 1 |
| NCBI Synonym Full Names: | GRB2 associated binding protein 1 |
| NCBI Official Symbol: | GAB1 |
| NCBI Protein Information: | GRB2-associated-binding protein 1 |
| UniProt Protein Name: | GRB2-associated-binding protein 1 |
| UniProt Synonym Protein Names: | GRB2-associated binder 1; Growth factor receptor bound protein 2-associated protein 1 |
| Protein Family: | GPI transamidase component |
| UniProt Gene Name: | GAB1 |
| UniProt Entry Name: | GAB1_HUMAN |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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