FOXC1/FOXC2 Antibody (PACO02739)
- SKU:
- PACO02739
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
| Antibody Name: | FOXC1/FOXC2 Antibody |
| Antibody SKU: | PACO02739 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from the Internal region of human FoxC1/2. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | FOXC1; FKHL7; FREAC3; Forkhead box protein C1; Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; FREAC-3; FOXC2; FKHL14; MFH1; Forkhead box protein C2; Forkhead-related protein FKHL14; Mesenchyme fork head protein 1; |
| UniProt Protein Function: | FOXC1: Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Monomer. Expressed in all tissues and cell lines examined. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding; Cell cycle regulation; Cell development/differentiation Chromosomal Location of Human Ortholog: 6p25 Cellular Component: cytoplasm; nuclear heterochromatin; nucleoplasm; nucleus Molecular Function:DNA bending activity; DNA binding; protein binding; sequence-specific DNA binding; transcription factor activity; transcription factor binding Biological Process: cell migration; cell proliferation; eye development; heart development; mesenchymal cell development; negative regulation of angiogenesis; negative regulation of mitotic cell cycle; odontogenesis of dentine-containing teeth; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent Disease: Axenfeld-rieger Syndrome, Type 3; Iridogoniodysgenesis, Type 1 |
| NCBI Summary: | This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q12948 |
| NCBI GenInfo Identifier: | 13638267 |
| NCBI Gene ID: | 2296 |
| NCBI Accession: | Q12948.3 |
| UniProt Secondary Accession: | Q12948,Q86UP7, Q9BYM1, Q9NUE5, Q9UDD0, Q9UP06, |
| UniProt Related Accession: | Q12948 |
| Molecular Weight: | 56,789 Da |
| NCBI Full Name: | Forkhead box protein C1 |
| NCBI Synonym Full Names: | forkhead box C1 |
| NCBI Official Symbol: | FOXC1 |
| NCBI Official Synonym Symbols: | ARA; IGDA; IHG1; FKHL7; IRID1; RIEG3; FREAC3; FREAC-3 |
| NCBI Protein Information: | forkhead box protein C1 |
| UniProt Protein Name: | Forkhead box protein C1 |
| UniProt Synonym Protein Names: | Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; FREAC-3 |
| Protein Family: | Forkhead box protein |
| UniProt Gene Name: | FOXC1 |
| UniProt Entry Name: | FOXC1_HUMAN |
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