| UniProt Protein Function: | FHIT: a member of the histidine triad gene family. A diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. Its gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. A possible tumor suppressor in specific tissues. Phospho-FHIT observed in liver and kidney, but not in brain and lung. Phospho-FHIT undetected in all tested human tumor cell lines. Aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas.Protein type: Motility/polarity/chemotaxis; Tumor suppressor; Hydrolase; DNA replication; EC 3.6.1.29; Nucleotide Metabolism - purineCellular Component: cytoplasm; cytosol; intracellular; nucleus; plasma membraneMolecular Function: bis(5'-adenosyl)-triphosphatase activity; catalytic activity; hydrolase activity; identical protein binding; nickel ion binding; nucleotide binding; ubiquitin protein ligase bindingBiological Process: apoptosis; diadenosine triphosphate catabolic process; DNA replication; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; nucleotide metabolic process; purine nucleotide metabolic process; regulation of transcription, DNA-dependent; transcription, DNA-dependent |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the HIT family of proteins that are characterized by the presence of a histidine triad sequence. The encoded protein is a diadenosine triphosphate hydrolase enzyme that cleaves the P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. This locus is very fragile and has been found to be altered in different types of cancers. Mice lacking the encoded protein display increased susceptibility to spontaneous and induced tumors. Ectopic expression of the encoded protein in such knockout mice inhibits tumor development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015] |
| UniProt Code: | O89106 |
| NCBI GenInfo Identifier: | 815930058 |
| NCBI Gene ID: | 14198 |
| NCBI Accession: | NP_001295215.1 |
| UniProt Secondary Accession: | O89106,Q6URW5, Q91VL1 |
| UniProt Related Accession: | O89106 |
| Molecular Weight: | 19.1 kDa |
| NCBI Full Name: | bis(5'-adenosyl)-triphosphatase isoform 2 |
| NCBI Synonym Full Names: | fragile histidine triad gene |
| NCBI Official Symbol: | Fhit |
| NCBI Official Synonym Symbols: | Fra14A2; AW045638 |
| NCBI Protein Information: | bis(5'-adenosyl)-triphosphatase |
| UniProt Protein Name: | Bis(5'-adenosyl)-triphosphatase |
| UniProt Synonym Protein Names: | AP3A hydrolase; AP3Aase; Diadenosine 5',5'''-P1,P3-triphosphate hydrolase; Dinucleosidetriphosphatase; Fragile histidine triad protein |
| Protein Family: | Bis(5'-adenosyl)-triphosphatase |
| UniProt Gene Name: | Fhit |
| UniProt Entry Name: | FHIT_MOUSE |
