FEM1A Antibody (PACO19654)
- SKU:
- PACO19654
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | FEM1A Antibody (PACO19654) |
| Antibody SKU: | PACO19654 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human FEM1A |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO19654(FEM1A Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19654(FEM1A Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | FEM1A (FEM-1 homolog a), also known as EPRAP (Prostaglandin E receptor 4-associated protein), is a 669 amino acid, cytoplasmic protein that belongs to the FEM-1 family. FEM1A is present in atheromata and in macrophages derived from peripheral blood monocytes. FEM1A may be a component of an E3 ubiquitin-protein ligase complex and functions as a substrate recognition subunit. It is suggested that FEM1A participates in anti-inflammatory signaling of macrophages via its interaction with EP4. FEM1A is down-regulated in Rhabdomyosarcoma, the most common soft tissue neoplasm of children. FEM1A is considered a candidate gene for polycystic ovary syndrome. |
| Synonyms: | fem-1 homolog a (C. elegans) |
| UniProt Protein Function: | FEM1A: Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. May participate in antiinflammatory signaling via its interaction with PTGER4. Belongs to the fem-1 family. |
| UniProt Protein Details: | Protein type:Ubiquitin conjugating system; Ligase Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: cytoplasm Molecular Function:EP4 subtype prostaglandin E2 receptor binding; ubiquitin-protein ligase activity Biological Process: regulation of ubiquitin-protein ligase activity; negative regulation of inflammatory response; protein ubiquitination |
| UniProt Code: | Q9BSK4 |
| NCBI GenInfo Identifier: | 24308163 |
| NCBI Gene ID: | 55527 |
| NCBI Accession: | NP_061178.1 |
| UniProt Secondary Accession: | Q9BSK4,Q711P8, Q9NPN7, Q9NPW8, B2RDI3, |
| UniProt Related Accession: | Q9BSK4 |
| Molecular Weight: | 73,639 Da |
| NCBI Full Name: | protein fem-1 homolog A |
| NCBI Synonym Full Names: | fem-1 homolog a (C. elegans) |
| NCBI Official Symbol: | FEM1A |
| NCBI Official Synonym Symbols: | EPRAP |
| NCBI Protein Information: | protein fem-1 homolog A |
| UniProt Protein Name: | Protein fem-1 homolog A |
| UniProt Synonym Protein Names: | FEM1-alpha; Prostaglandin E receptor 4-associated protein |
| Protein Family: | Protein |
| UniProt Gene Name: | FEM1A |
| UniProt Entry Name: | FEM1A_HUMAN |
| Antibodies | ELISA Kits |
| Anti-FEM1A Antibody (CAB16129) | Human FEM1A ELISA Kit |
| FEM1A Antibody (PACO09273) | Human Protein fem-1 homolog A (FEM1A) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
Anti-FEM1A Antibody (CAB16129)
Human FEM1A ELISA Kit
Human Protein fem-1 homolog A (FEM1A) ELISA Kit
