UniProt Protein Function: | FBXO31: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor. Part of a SCF (SKP1-cullin-F-box) protein ligase complex. By DNA damage. Increases after UV irradiation, X-ray irradiation, oxidative stress (H(2)O(2)) or addition of the chemotherapeutic DNA-damaging agents etoposide, adriamycin, cisplatin or fluorouracil. Highly expressed in brain. Expressed at moderate levels in most tissues, except bone marrow. Belongs to the FBXO31 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cell cycle regulation; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 16q24.2 Cellular Component: cell soma; cytosol; SCF ubiquitin ligase complex Molecular Function:cyclin binding; ubiquitin-protein ligase activity Biological Process: cyclin catabolic process; G1 DNA damage checkpoint; protein polyubiquitination; response to DNA damage stimulus; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Disease: Mental Retardation, Autosomal Recessive 45 |
NCBI Summary: | This gene is a member of the F-box family. Members are classified into three classes according to the substrate interaction domain, FBW for WD40 repeats, FBL for leucing-rich repeats, and FBXO for other domains. This protein, classified into the last category because of the lack of a recognizable substrate binding domain, has been proposed to be a component of the SCF ubiquitination complex. It is thought to bind and recruit substrate for ubiquitination and degradation. This protein may have a role in regulating the cell cycle as well as dendrite growth and neuronal migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] |
UniProt Code: | Q5XUX0 |
NCBI GenInfo Identifier: | 146345419 |
NCBI Gene ID: | 79791 |
NCBI Accession: | Q5XUX0.2 |
UniProt Secondary Accession: | Q5XUX0,Q5K680, Q8WYV1, Q96D73, Q9UFV4, |
UniProt Related Accession: | Q5XUX0 |
Molecular Weight: | 49,039 Da |
NCBI Full Name: | F-box only protein 31 |
NCBI Synonym Full Names: | F-box protein 31 |
NCBI Official Symbol: | FBXO31 |
NCBI Official Synonym Symbols: | FBX14; Fbx31; MRT45; FBXO14; pp2386 |
NCBI Protein Information: | F-box only protein 31 |
UniProt Protein Name: | F-box only protein 31 |
Protein Family: | F-box only protein |
UniProt Gene Name: | FBXO31 |
UniProt Entry Name: | FBX31_HUMAN |