ETS1 Transcription Factor Activity Assay
- SKU:
- TFAB00098
- Product Type:
- ELISA Kit
- ELISA Type:
- Transcription Factor Assay
- Analytes:
- ETS1
- Reactivity:
- Human
- Mouse
Description
ETS1 Transcription Factor Activity Assay
The ETS1 Transcription Factor Activity Assay is a highly sensitive and specific kit designed for the precise measurement of ETS1 transcription factor activity in various biological samples. This assay kit provides researchers with reliable and reproducible results, making it an essential tool for studying gene regulation and cellular processes.ETS1 is a key transcription factor that plays a critical role in regulating gene expression and cell differentiation. Its dysregulation has been linked to various diseases, including cancer, autoimmune disorders, and inflammatory conditions.
By accurately measuring ETS1 activity, researchers can gain valuable insights into the molecular mechanisms underlying these diseases and potentially identify new therapeutic targets.With its user-friendly protocol and high-performance capabilities, the ETS1 Transcription Factor Activity Assay is suitable for a wide range of research applications, offering researchers a valuable tool for advancing their understanding of gene regulation and disease pathogenesis.
| Product Name: | ETS1 Transcription Factor Activity Assay |
| Product Code: | TFAB00098 |
| Target: | ETS1 |
| Synonyms: | p54 |
| Reactivity: | Human, Mouse |
| Sample Types: | Nuclear or cell lysates |
The Assay Genie ETS1 transcription factor activity assay allows for the detection and qualitative analysis of endogenous levels of activated transcription factors in a variety of nuclear and cell lysates
Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.
| Assay Time: | 4.5 hours |
| Detection Method: | Colorimetric 450 nm |
| Size: | 12 x 8-Well Microstrips |
| Storage: | 4°C for 6 months |
| UniProt Protein Function: | Ets-1: a proto-oncogenic transcription factor homologous to the v-ets erythroblastosis virus oncogene. The DNA binding activity of Ets1 is controlled by kinases and transcription factors. It contributes to the regulation of cellular differentiation in hematopoietic cells. Ets1 promotes invasive behavior in endothelial cells, vascular smooth muscle cells and epithelial cancer cells. Regulates the expression of MMP1, MMP3, MMP9 and uPA as well as of VEGF and VEGFR gene expression. Two alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor Chromosomal Location of Human Ortholog: 11q23.3 Cellular Component: nucleoplasm; nucleus Molecular Function:DNA binding; identical protein binding; protein binding; transcription factor activity Biological Process: cell motility involved in cell locomotion; immune response; negative regulation of cell proliferation; PML body organization and biogenesis; positive regulation of cell motility; positive regulation of erythrocyte differentiation; positive regulation of inflammatory response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of angiogenesis |
| NCBI Summary: | This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011] |
| UniProt Code: | P14921 |
| NCBI GenInfo Identifier: | 119641 |
| NCBI Gene ID: | 2113 |
| NCBI Accession: | P14921.1 |
| UniProt Secondary Accession: | P14921,Q14278, Q16080, Q6N087, Q96AC5, A9UL17, F5GYX9 |
| UniProt Related Accession: | P14921 |
| Molecular Weight: | 30,860 Da |
| NCBI Full Name: | Protein C-ets-1 |
| NCBI Synonym Full Names: | ETS proto-oncogene 1, transcription factor |
| NCBI Official Symbol: | ETS1 |
| NCBI Official Synonym Symbols: | p54; ETS-1; EWSR2; c-ets-1 |
| NCBI Protein Information: | protein C-ets-1 |
| UniProt Protein Name: | Protein C-ets-1 |
| UniProt Synonym Protein Names: | p54 |
| Protein Family: | Protein |
| UniProt Gene Name: | ETS1 |
| UniProt Entry Name: | ETS1_HUMAN |
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