EARS2 Antibody (PACO52430)
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주문- SKU:
- PACO52430
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | EARS2 Antibody (PACO52430) |
Antibody SKU: | PACO52430 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Probable glutamate--tRNA ligase, mitochondrial protein (42-166AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human ovarian cancer using PACO52430 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO52430 at dilution of 1:100. |
Background: | Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). |
Synonyms: | Probable glutamate--tRNA ligase, mitochondrial (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS), EARS2, KIAA1970 |
UniProt Protein Function: | EARS2: Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). Belongs to the class-I aminoacyl-tRNA synthetase family. |
UniProt Protein Details: | Protein type:Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Mitochondrial; Translation; EC 6.1.1.17; Ligase Chromosomal Location of Human Ortholog: 16p12.2 Cellular Component: mitochondrion Molecular Function:glutamate-tRNA ligase activity; glutamate-tRNA(Gln) ligase activity; RNA binding Biological Process: glutamyl-tRNA aminoacylation Disease: Combined Oxidative Phosphorylation Deficiency 12 |
NCBI Summary: | This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of glutamate to tRNA molecules. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency 12 (COXPD12). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015] |
UniProt Code: | Q5JPH6 |
NCBI GenInfo Identifier: | 117949790 |
NCBI Gene ID: | 124454 |
NCBI Accession: | Q5JPH6.2 |
UniProt Secondary Accession: | Q5JPH6,Q86YH3, Q8TF31, B3KTT2, D3DWF1, |
UniProt Related Accession: | Q5JPH6 |
Molecular Weight: | 59,989 Da |
NCBI Full Name: | Probable glutamate--tRNA ligase, mitochondrial |
NCBI Synonym Full Names: | glutamyl-tRNA synthetase 2, mitochondrial |
NCBI Official Symbol: | EARS2 |
NCBI Official Synonym Symbols: | MSE1; gluRS; COXPD12 |
NCBI Protein Information: | probable glutamate--tRNA ligase, mitochondrial |
UniProt Protein Name: | Probable glutamate--tRNA ligase, mitochondrial |
UniProt Synonym Protein Names: | Glutamyl-tRNA synthetase; GluRS |
Protein Family: | Probable glutamate--tRNA ligase |
UniProt Gene Name: | EARS2 |
UniProt Entry Name: | SYEM_HUMAN |
Antibodies |
Anti-EARS2 Antibody (CAB14959) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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