| UniProt Protein Function: | DNAJC6: Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor); Chaperone; EC 3.1.3.48Chromosomal Location of Human Ortholog: 1p31.3Cellular Component: cytosolDisease: Parkinson Disease 19, Juvenile-onset |
| UniProt Protein Details: | |
| NCBI Summary: | DNAJC6 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus, a glycine/phenylalanine (G/F)-rich region, and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain (Ohtsuka and Hata, 2000 [PubMed 11147971]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | O75061 |
| NCBI GenInfo Identifier: | 109818722 |
| NCBI Gene ID: | 9829 |
| NCBI Accession: | O75061.3 |
| UniProt Secondary Accession: | O75061,Q32M66, Q4G0K1, Q5T614, Q5T615, B7Z3V8, D3DQ65 D3DQ66 |
| UniProt Related Accession: | O75061 |
| Molecular Weight: | 98,649 Da |
| NCBI Full Name: | Putative tyrosine-protein phosphatase auxilin |
| NCBI Synonym Full Names: | DnaJ heat shock protein family (Hsp40) member C6 |
| NCBI Official Symbol: | DNAJC6 |
| NCBI Official Synonym Symbols: | DJC6; PARK19 |
| NCBI Protein Information: | putative tyrosine-protein phosphatase auxilin |
| UniProt Protein Name: | Putative tyrosine-protein phosphatase auxilin |
| UniProt Synonym Protein Names: | DnaJ homolog subfamily C member 6 |
| Protein Family: | Putative tyrosine-protein phosphatase auxilin |
| UniProt Gene Name: | DNAJC6 |
| UniProt Entry Name: | AUXI_HUMAN |
