| UniProt Protein Function: | CYP8B1: Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha- hydroxylated C27 steroids. Belongs to the cytochrome P450 family.Protein type: Lipid Metabolism - primary bile acid biosynthesis; Membrane protein, integral; EC 1.14.13.95; OxidoreductaseChromosomal Location of Human Ortholog: 3p22.1Cellular Component: endoplasmic reticulum membraneMolecular Function: 7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity; oxygen binding; sterol 12-alpha-hydroxylase activityBiological Process: bile acid biosynthetic process; sterol metabolic process |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these two steroids determines the relative amounts of cholic acid and chenodeoxycholic acid both of which are secreted in the bile and affect the solubility of cholesterol. This gene is unique among the cytochrome P450 genes in that it is intronless. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UNU6 |
| NCBI GenInfo Identifier: | 308153428 |
| NCBI Gene ID: | 1582 |
| NCBI Accession: | Q9UNU6.2 |
| UniProt Secondary Accession: | Q9UNU6,O75958, Q6NWT2, Q6NWT3, B2RCY3 |
| UniProt Related Accession: | Q9UNU6 |
| Molecular Weight: | 58,068 Da |
| NCBI Full Name: | 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase |
| NCBI Synonym Full Names: | cytochrome P450 family 8 subfamily B member 1 |
| NCBI Official Symbol: | CYP8B1 |
| NCBI Official Synonym Symbols: | CP8B; CYP12 |
| NCBI Protein Information: | 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase |
| UniProt Protein Name: | 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase |
| UniProt Synonym Protein Names: | 7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase; CYPVIIIB1; Cytochrome P450 8B1; Sterol 12-alpha-hydroxylase |
| Protein Family: | 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase |
| UniProt Gene Name: | CYP8B1 |
| UniProt Entry Name: | CP8B1_HUMAN |
