Ctss Antibody (PACO26041)
- SKU:
- PACO26041
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Ctss Antibody (PACO26041) |
| Antibody SKU: | PACO26041 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Mouse |
| Immunogen: | Recombinant Mouse Cathepsin S protein (123-340AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N. |
| Synonyms: | Cathepsin S (EC 3.4.22.27), Ctss, Cats |
| UniProt Protein Function: | CTSS: Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N. Belongs to the peptidase C1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.22.27; Protease Chromosomal Location of Human Ortholog: 3 F2.1|3 40.74 cM Cellular Component: cell surface; extracellular space; intracellular membrane-bound organelle; lysosome; membrane Molecular Function:collagen binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity; fibronectin binding; laminin binding; peptidase activity; proteoglycan binding Biological Process: antigen processing and presentation; antigen processing and presentation of peptide antigen; bone resorption; collagen catabolic process; immune response; positive regulation of inflammatory response; protein processing; proteolysis; proteolysis involved in cellular protein catabolic process; regulation of sensory perception of pain; response to acidity |
| NCBI Summary: | This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. Alternative splicing results in multiple transcript variants, which encode preproproteins that are proteolytically processed to generate mature protein products. This enzyme is secreted by antigen-presenting cells during inflammation and may induce pain and itch via activation of G-protein coupled receptors. Homozygous knockout mice for this gene exhibit impaired wound healing, reduced tumorigenesis in a pancreatic cancer model, and reduced pathogenesis in a myasthenia gravis model. [provided by RefSeq, Aug 2015] |
| UniProt Code: | O70370 |
| NCBI GenInfo Identifier: | 510025483 |
| NCBI Gene ID: | 13040 |
| NCBI Accession: | NP_067256.4 |
| UniProt Secondary Accession: | O70370,O54973, E9QK18, |
| UniProt Related Accession: | O70370 |
| Molecular Weight: | 27.8kD |
| NCBI Full Name: | cathepsin S isoform 2 preproprotein |
| NCBI Synonym Full Names: | cathepsin S |
| NCBI Official Symbol: | Ctss |
| NCBI Official Synonym Symbols: | Cats |
| NCBI Protein Information: | cathepsin S |
| UniProt Protein Name: | Cathepsin S |
| Protein Family: | Cathepsin |
| UniProt Gene Name: | Ctss |
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