CSF2RA Antibody (PACO25981)
- SKU:
- PACO25981
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | CSF2RA Antibody (PACO25981) |
Antibody SKU: | PACO25981 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:200-1:500 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Granulocyte-macrophage colony-stimulating factor receptor subunit α protein (23-320AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemistry of paraffin-embedded human testis tissue using PACO25981 at dilution of 1:100. | |
Immunofluorescence staining of HepG2 cells with PACO25981 at 1:466, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). | |
Immunohistochemistry of paraffin-embedded human skin tissue using PACO25981 at dilution of 1:100. |
Background: | Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. |
Synonyms: | Granulocyte-macrophage colony-stimulating factor receptor subunit α (GM-CSF-R-alpha) (GMCSFR-alpha) (GMR-alpha) (CDw116) (CD antigen CD116), CSF2RA, CSF2R CSF2RY |
UniProt Protein Function: | CSF2RA: Low affinity receptor for granulocyte-macrophage colony- stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. Defects in CSF2RA are the cause of pulmonary surfactant metabolism dysfunction type 4 (SMDP4). A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. Belongs to the type I cytokine receptor family. Type 5 subfamily. 8 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, cytokine Chromosomal Location of Human Ortholog: Xp22.32 and Yp11.3 Cellular Component: extracellular region; integral to plasma membrane; intracellular; plasma membrane Molecular Function:granulocyte colony-stimulating factor binding; granulocyte colony-stimulating factor receptor activity; protein binding; receptor activity Biological Process: activation of MAPKK activity; axon guidance; cellular protein metabolic process; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; innate immune response; insulin receptor signaling pathway; MAPKKK cascade; nerve growth factor receptor signaling pathway; Ras protein signal transduction; small GTPase mediated signal transduction; vascular endothelial growth factor receptor signaling pathway Disease: Surfactant Metabolism Dysfunction, Pulmonary, 4 |
NCBI Summary: | The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq, Jul 2008] |
UniProt Code: | P15509 |
NCBI GenInfo Identifier: | 121509 |
NCBI Gene ID: | 1438 |
NCBI Accession: | P15509.1 |
UniProt Secondary Accession: | P15509,O00207, Q14429, Q14430, Q14431, Q16564, A7J003 A8KAM1, B4DW68, J3JS76, J3JS77, |
UniProt Related Accession: | P15509 |
Molecular Weight: | 31,101 Da |
NCBI Full Name: | Granulocyte-macrophage colony-stimulating factor receptor subunit alpha |
NCBI Synonym Full Names: | colony stimulating factor 2 receptor alpha subunit |
NCBI Official Symbol: | CSF2RA |
NCBI Official Synonym Symbols: | GMR; CD116; CSF2R; SMDP4; CDw116; CSF2RX; CSF2RY; GMCSFR; CSF2RAX; CSF2RAY; GM-CSF-R-alpha |
NCBI Protein Information: | granulocyte-macrophage colony-stimulating factor receptor subunit alpha |
UniProt Protein Name: | Granulocyte-macrophage colony-stimulating factor receptor subunit alpha |
UniProt Synonym Protein Names: | CDw116; CD_antigen: CD116 |
Protein Family: | Granulocyte-macrophage colony-stimulating factor receptor |
UniProt Gene Name: | CSF2RA |
UniProt Entry Name: | CSF2R_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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