CPN1 Antibody (PACO44871)
- SKU:
- PACO44871
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | CPN1 Antibody (PACO44871) |
| Antibody SKU: | PACO44871 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Carboxypeptidase N catalytic chain protein (209-458AA) |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human liver tissue using PACO44871 at dilution of 1:100. |
| Background: | Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation. |
| Synonyms: | Carboxypeptidase N catalytic chain (CPN) (EC 3.4.17.3) (Anaphylatoxin inactivator) (Arginine carboxypeptidase) (Carboxypeptidase N polypeptide 1) (Carboxypeptidase N small subunit) (Kininase-1) (Lysine carboxypeptidase) (Plasma carboxypeptidase B) (Serum carboxypeptidase N) (SCPN), CPN1, ACBP |
| UniProt Protein Function: | CPN1: Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation. Defects in CPN1 are the cause of carboxypeptidase N deficiency (CPND). Patients affected present some combination of angioedema or chronic urticaria, as well as hay fever or astma, and have also slightly depressed serum carboxy peptidase N, suggestive of autosomal recessive inheritance of this disorder. Belongs to the peptidase M14 family. |
| UniProt Protein Details: | Protein type:Secreted; EC 3.4.17.3; Protease; Secreted, signal peptide Chromosomal Location of Human Ortholog: 10q24.2 Molecular Function:serine carboxypeptidase activity Biological Process: peptide metabolic process; protein processing Disease: Carboxypeptidase N Deficiency |
| NCBI Summary: | Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P15169 |
| NCBI GenInfo Identifier: | 115896 |
| NCBI Gene ID: | 1369 |
| NCBI Accession: | P15169.1 |
| UniProt Secondary Accession: | P15169,B1AP59, |
| UniProt Related Accession: | P15169 |
| Molecular Weight: | 52,286 Da |
| NCBI Full Name: | Carboxypeptidase N catalytic chain |
| NCBI Synonym Full Names: | carboxypeptidase N subunit 1 |
| NCBI Official Symbol: | CPN1 |
| NCBI Official Synonym Symbols: | CPN; SCPN |
| NCBI Protein Information: | carboxypeptidase N catalytic chain |
| UniProt Protein Name: | Carboxypeptidase N catalytic chain |
| UniProt Synonym Protein Names: | Anaphylatoxin inactivator; Arginine carboxypeptidase; Carboxypeptidase N polypeptide 1; Carboxypeptidase N small subunit; Kininase-1; Lysine carboxypeptidase; Plasma carboxypeptidase B; Serum carboxypeptidase N; SCPN |
| Protein Family: | Carboxypeptidase |
| UniProt Gene Name: | CPN1 |
| UniProt Entry Name: | CBPN_HUMAN |
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