COX17 Antibody (PACO35582)
- SKU:
- PACO35582
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | COX17 Antibody (PACO35582) |
| Antibody SKU: | PACO35582 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Cytochrome c oxidase copper chaperone protein (1-63AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: COX17 antibody at 3.5µg/ml + HepG2 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 7 kDa. Observed band size: 7 kDa. |
 | Immunohistochemistry of paraffin-embedded human brain tissue using PACO35582 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human liver tissue using PACO35582 at dilution of 1:100. |
| Background: | Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2). |
| Synonyms: | Cytochrome c oxidase copper chaperone, COX17 |
| UniProt Protein Function: | COX17: Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX. Belongs to the COX17 family.Protein type: Mitochondrial; Energy Metabolism - oxidative phosphorylationChromosomal Location of Human Ortholog: 3q13.33Cellular Component: mitochondrion; cytoplasm; mitochondrial intermembrane spaceMolecular Function: copper ion binding; copper chaperone activityBiological Process: generation of precursor metabolites and energy; heart development; brain development; copper ion transport |
| UniProt Protein Details: | |
| NCBI Summary: | Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14061 |
| NCBI GenInfo Identifier: | 5031645 |
| NCBI Gene ID: | 10063 |
| NCBI Accession: | NP_005685 |
| UniProt Secondary Accession: | Q14061 |
| UniProt Related Accession: | Q14061 |
| Molecular Weight: | |
| NCBI Full Name: | cytochrome c oxidase copper chaperone isoform b |
| NCBI Synonym Full Names: | cytochrome c oxidase copper chaperone COX17 |
| NCBI Official Symbol: | COX17 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | cytochrome c oxidase copper chaperone |
| UniProt Protein Name: | Cytochrome c oxidase copper chaperone |
| UniProt Synonym Protein Names: | |
| Protein Family: | Cytochrome c oxidase copper chaperone |
| UniProt Gene Name: | COX17 |
| UniProt Entry Name: | COX17_HUMAN |
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